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10.1002/cyto.a.24190 http://scihub22266oqcxt.onion/10.1002/cyto.a.24190 32686260!7404934!32686260     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytometry+A 2020 ; 97 (9): 872-881 Nephropedia Template TP {{tp|p=32686260|t=2020. Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19 |pdf=|usr=}}{{32686260}} gab.com Text Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19 JO: Cytometry A http://www.kidney.de/pget.php?&tw=1&pmid=32686260 #FOAvip Malaria is a threat to human mankind and kills about half a million people every year. On the other hand, COVID-19 resulted in several hundred thousand deaths since December 2019 and remains without an efficient and safe treatment. The antimalarials chloroquine (CQ) and its analog, hydroxychloroquine (HCQ), have been tested for COVID-19 treatment, and several conflicting evidence has been obtained. Therefore, the aim of this review was to summarize the evidence regarding action mechanisms of these compounds against Plasmodium and SARS-CoV-2 infection, together with cytometry applications. CQ and HCQ act on the renin angiotensin system, with possible implications on the cardiorespiratory system. In this context, flow and image cytometry emerge as powerful technologies to investigate the mechanism of therapeutic candidates, as well as for the identification of the immune response and prognostics of disease severity. Data from the large randomized trials support the conclusion that CQ and HCQ do not provide any clinical improvements in disease severity and progression of SARS-CoV-2 patients, as well as they do not present any solid evidence of increased serious side effects. These drugs are safe and effective antimalarials agents, but in SARS-CoV-2 patients, they need further studies in the context of clinical trials. (c) 2020 International Society for Advancement of Cytometry. Twit Text FOAVip Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19 ????Cytometry A http://www.kidney.de/pget.php?&tw=1&pmid=32686260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32686260 #FOAvip English Wikipedia <ref>{{Cite pmid|32686260}}</ref> Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19 #MMPMID32686260 Pillat MM; Kruger A; Guimaraes LMF; Lameu C; de Souza EE; Wrenger C; Ulrich H Cytometry A 2020[Sep]; 97 (9): 872-881 PMID32686260show ga Malaria is a threat to human mankind and kills about half a million people every year. On the other hand, COVID-19 resulted in several hundred thousand deaths since December 2019 and remains without an efficient and safe treatment. The antimalarials chloroquine (CQ) and its analog, hydroxychloroquine (HCQ), have been tested for COVID-19 treatment, and several conflicting evidence has been obtained. Therefore, the aim of this review was to summarize the evidence regarding action mechanisms of these compounds against Plasmodium and SARS-CoV-2 infection, together with cytometry applications. CQ and HCQ act on the renin angiotensin system, with possible implications on the cardiorespiratory system. In this context, flow and image cytometry emerge as powerful technologies to investigate the mechanism of therapeutic candidates, as well as for the identification of the immune response and prognostics of disease severity. Data from the large randomized trials support the conclusion that CQ and HCQ do not provide any clinical improvements in disease severity and progression of SARS-CoV-2 patients, as well as they do not present any solid evidence of increased serious side effects. These drugs are safe and effective antimalarials agents, but in SARS-CoV-2 patients, they need further studies in the context of clinical trials. (c) 2020 International Society for Advancement of Cytometry. |Animals[MESH] |Antimalarials/adverse effects/*therapeutic use[MESH] |Antiviral Agents/adverse effects/*therapeutic use[MESH] |Betacoronavirus/*drug effects/immunology/pathogenicity[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/adverse effects/*therapeutic use[MESH] |Coronavirus Infections/diagnosis/*drug therapy/immunology/virology[MESH] |Flow Cytometry[MESH] |Host Microbial Interactions[MESH] |Host-Parasite Interactions[MESH] |Humans[MESH] |Malaria/diagnosis/*drug therapy/immunology/parasitology[MESH] |Pandemics[MESH] |Plasmodium/*drug effects/immunology/pathogenicity[MESH] |Pneumonia, Viral/diagnosis/*drug therapy/immunology/virology[MESH] |SARS-CoV-2[MESH]Insights in Chloroquine Action: Perspectives and Implications in Malar(epmc).pdf DeepDyve Pubget Overpricing