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10.1002/rth2.12390

http://scihub22266oqcxt.onion/10.1002/rth2.12390
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32685905!7276726!32685905
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suck abstract from ncbi


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pmid32685905      Res+Pract+Thromb+Haemost 2020 ; 4 (5): 936-941
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  • Heparin-induced thrombocytopenia with thrombosis in COVID-19 adult respiratory distress syndrome #MMPMID32685905
  • Riker RR; May TL; Fraser GL; Gagnon DJ; Bandara M; Zemrak WR; Seder DB
  • Res Pract Thromb Haemost 2020[Jul]; 4 (5): 936-941 PMID32685905show ga
  • Early reports of coronavirus disease 2019 (COVID-19) clinical features describe a hypercoagulable state, and recent guidelines recommend prophylactic anticoagulation for patients with COVID-19 with low-molecular-weight heparin, but this would be contraindicated in the presence of heparin-induced thrombocytopenia (HIT). We address the key clinical question whether HIT is also present during COVID-19. We report 3 cases of thrombocytopenia with antiplatelet factor 4 antibodies among 16 intubated patients with COVID-19 with adult respiratory distress syndrome, a higher-than-expected incidence of 19%. Each patient had evidence of thrombosis (pulmonary embolism, upper extremity venous thromboses, and skin necrosis, respectively). The serotonin release assay confirmed HIT in 1 case, and 2 cases were negative. We believe this is the first reported case of HIT during the COVID-19 pandemic. Recognition that the thrombocytopenia represented HIT in the confirmed case was delayed. We recommend clinicians monitor platelet counts closely during heparin therapy, with a low threshold to evaluate for HIT.
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