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10.1155/2020/3152043 http://scihub22266oqcxt.onion/10.1155/2020/3152043 32685466!7322586!32685466     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2020 ; 2020 (ä): 3152043 Nephropedia Template TP {{tp|p=32685466|t=2020. Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-kappaB Signaling Pathway |pdf=|usr=}}{{32685466}} gab.com Text Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-kappaB Signaling Pathway JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32685466 #FOAvip Tec kinase is an important mediator in inflammatory immune response that enhances the activity of neutrophils and macrophages. However, information on its function in lipopolysaccharide- (LPS-) induced acute kidney injury (AKI) is limited. This study is aimed at determining whether Tec kinase was a regulator in AKI. An AKI model in mice was successfully established using intraperitoneal LPS. Results showed that the serum levels of creatinine (Cr), blood urea nitrogen (BUN), and cystatin-C (Cys-C) increased after intraperitoneal LPS injection. Renal tissue sustained significantly severe injury as measured by pathological scores. Pretreatment with LFM-A13 improved the function of the kidney in mice and decreased the renal injury score. Enzyme-linked immunosorbent assay showed that LFM-A13 significantly reduced the release of IL-1beta and TNF-alpha in mice exposed to LPS. LFM-A13 can evidently abrogate the expression of Tec protein, MyD88, TLR4, NF-kappaB p65, and Tec's phosphorylated protein as determined by Western blot. Immunohistochemistry analysis revealed that LFM-A13 markedly downregulated the expression of Tec kinase in renal tubular epithelial cells. In vitro, Tec kinase protein was expressed highly in NRK-52E cells after LPS exposure. Tec-siRNA also decreased IL-1beta and TNF-alpha production and obviously abolished phospho-p65 and phospho-IkappaBalpha expression in NRK-52E cell stimulated by LPS; however, Tec-siRNA increased the IkappaBalpha level. Altogether, these data suggested that Tec kinase can be a modulating protein in AKI through TLR4/NF-kappaB activation. Twit Text FOAVip Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-kappaB Signaling Pathway ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32685466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32685466 #FOAvip English Wikipedia <ref>{{Cite pmid|32685466}}</ref> Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-kappaB Signaling Pathway #MMPMID32685466 Zhang W; Zhou P; Jiang X; Fan Z; Xu X; Wang F Biomed Res Int 2020[]; 2020 (ä): 3152043 PMID32685466show ga Tec kinase is an important mediator in inflammatory immune response that enhances the activity of neutrophils and macrophages. However, information on its function in lipopolysaccharide- (LPS-) induced acute kidney injury (AKI) is limited. This study is aimed at determining whether Tec kinase was a regulator in AKI. An AKI model in mice was successfully established using intraperitoneal LPS. Results showed that the serum levels of creatinine (Cr), blood urea nitrogen (BUN), and cystatin-C (Cys-C) increased after intraperitoneal LPS injection. Renal tissue sustained significantly severe injury as measured by pathological scores. Pretreatment with LFM-A13 improved the function of the kidney in mice and decreased the renal injury score. Enzyme-linked immunosorbent assay showed that LFM-A13 significantly reduced the release of IL-1beta and TNF-alpha in mice exposed to LPS. LFM-A13 can evidently abrogate the expression of Tec protein, MyD88, TLR4, NF-kappaB p65, and Tec's phosphorylated protein as determined by Western blot. Immunohistochemistry analysis revealed that LFM-A13 markedly downregulated the expression of Tec kinase in renal tubular epithelial cells. In vitro, Tec kinase protein was expressed highly in NRK-52E cells after LPS exposure. Tec-siRNA also decreased IL-1beta and TNF-alpha production and obviously abolished phospho-p65 and phospho-IkappaBalpha expression in NRK-52E cell stimulated by LPS; however, Tec-siRNA increased the IkappaBalpha level. Altogether, these data suggested that Tec kinase can be a modulating protein in AKI through TLR4/NF-kappaB activation. |Acute Kidney Injury/*enzymology/metabolism/pathology/prevention & control[MESH] |Amides/*pharmacology[MESH] |Animals[MESH] |Cell Line[MESH] |Disease Models, Animal[MESH] |Lipopolysaccharides/pharmacology[MESH] |Macrophages/drug effects/metabolism[MESH] |Male[MESH] |Mice[MESH] |Nitriles/*pharmacology[MESH] |Phosphorylation[MESH] |Protein Kinase Inhibitors/pharmacology[MESH] |Protein-Tyrosine Kinases/*antagonists & inhibitors/biosynthesis/*metabolism[MESH] |Signal Transduction[MESH] |Toll-Like Receptor 4/*metabolism[MESH]Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney (epmc).pdf DeepDyve Pubget Overpricing