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10.1016/j.vaccine.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.vaccine.2020.07.003
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suck abstract from ncbi


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pmid32684497      Vaccine 2020 ; 38 (36): 5742-5746
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  • Vaccines based on virus-like nano-particles for use against Middle East Respiratory Syndrome (MERS) coronavirus #MMPMID32684497
  • Hashemzadeh A; Avan A; Ferns GA; Khazaei M
  • Vaccine 2020[Aug]; 38 (36): 5742-5746 PMID32684497show ga
  • Recent advances in virus-like nanoparticles against Middle East respiratory syndrome-related coronavirus (MERS-CoV) can initiate vaccine production faster for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), while ensuring the safety, easy administration, and long-term effects. Patients with this viral pathogen suffer from excess mortality. MERS-CoV can spread through bioaerosol transmission from animal or human sources. The appearance of an outbreak in South Korea sparked off a strong urge to design strategies for developing an effective vaccine since the emergence of MERS-CoV in 2012. Well unfortunately, this is an important fact in virus risk management. The studies showed that virus-like nanoparticles (VLPs) could be effective in its goal of stopping the symptoms of MERS-CoV infection. Besides, due to the genetic similarities in the DNA sequencing of SARS-CoV-2 with MERS-CoV and the first identified severe acute respiratory syndrome (SARS-CoV) in China since 2002/2003, strategic approaches could be used to manage SARS-CoV 2. Gathering the vital piece of information obtained so far could lead to a breakthrough in the development of an effective vaccine against SARS-CoV-2, which is prioritized and focussed by the World Health Organization (WHO). This review focuses on the virus-like nanoparticle that got successful results in animal models of MERS-CoV.
  • |Animals[MESH]
  • |Betacoronavirus/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*prevention & control[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/*immunology[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/prevention & control[MESH]
  • |SARS-CoV-2[MESH]


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