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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Endocrinol+(Oxf) 2020 ; 93 (4): 390-393 Nephropedia Template TP
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COVID-19 and diabetes: Insulin requirements parallel illness severity in critically unwell patients #MMPMID32683745
Wu L; Girgis CM; Cheung NW
Clin Endocrinol (Oxf) 2020[Oct]; 93 (4): 390-393 PMID32683745show ga
OBJECTIVE: In the light of increased adverse outcomes for people with diabetes affected by COVID-19, we have described the clinical course of a cohort of critically ill patients with COVID-19 and diabetes. METHODS: We retrospectively analysed characteristics, glucometrics and inflammatory markers of patients with diabetes mellitus admitted to intensive care unit (ICU) with COVID-19. RESULTS: Eight patients with diabetes were admitted to ICU with COVID-19. All had type 2 diabetes, with three being newly diagnosed that admission. Mean HbA1c was 9.2%. Glucometric analysis indicated that extremely high insulin doses were required during peak inflammatory response to maintain glycaemic control with a mean peak insulin requirement of 201 units per day (2.2 units/kg/day). CONCLUSIONS: Critically unwell patients with diabetes mellitus and COVID-19 had high insulin requirements and poorer time in target range at the time of peak inflammatory response, and this improved as their illness resolved.
|*Critical Illness[MESH]
|*SARS-CoV-2[MESH]
|Adult[MESH]
|COVID-19/*complications[MESH]
|Cohort Studies[MESH]
|Diabetes Mellitus, Type 2/*complications/drug therapy/pathology[MESH]