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10.1002/dmrr.3388

http://scihub22266oqcxt.onion/10.1002/dmrr.3388
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32683744!7404605!32683744
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suck abstract from ncbi


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pmid32683744      Diabetes+Metab+Res+Rev 2021 ; 37 (3): e3388
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  • Characteristics and outcomes of COVID-19 in hospitalized patients with and without diabetes #MMPMID32683744
  • Al-Salameh A; Lanoix JP; Bennis Y; Andrejak C; Brochot E; Deschasse G; Dupont H; Goeb V; Jaureguy M; Lion S; Maizel J; Moyet J; Vaysse B; Desailloud R; Ganry O; Schmit JL; Lalau JD
  • Diabetes Metab Res Rev 2021[Mar]; 37 (3): e3388 PMID32683744show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) is a rapidly progressing pandemic, with four million confirmed cases and 280 000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID-19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs without diabetes. METHODS: All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID-19 up until April 21st, 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analysed separately in a logistic regression analysis and a Cox proportional hazards model. RESULTS: A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non-ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66-1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40-1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09-3.92, P = .027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death. CONCLUSIONS: Diabetes was prevalent in a quarter of the patients hospitalized with COVID-19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID-19 severity and diabetes is warranted.
  • |*COVID-19/complications/diagnosis/epidemiology/therapy[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Body Mass Index[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Diabetes Mellitus/*diagnosis/*epidemiology/mortality/therapy[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/*statistics & numerical data[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/physiology[MESH]
  • |Severity of Illness Index[MESH]


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