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Outcomes from COVID-19 across the range of frailty: excess mortality in fitter older people #MMPMID32683576
Miles A; Webb TE; Mcloughlin BC; Mannan I; Rather A; Knopp P; Davis D
Eur Geriatr Med 2020[Oct]; 11 (5): 851-855 PMID32683576show ga
PURPOSE: Our aim was to quantify the mortality from COVID-19 and identify any interactions with frailty and other demographic factors. METHODS: Hospitalised patients aged >/= 70 were included, comparing COVID-19 cases with non-COVID-19 controls admitted over the same period. Frailty was prospectively measured and mortality ascertained through linkage with national and local statutory reports. RESULTS: In 217 COVID-19 cases and 160 controls, older age and South Asian ethnicity, though not socioeconomic position, were associated with higher mortality. For frailty, differences in effect size were evident between cases (HR 1.02, 95% CI 0.93-1.12) and controls (HR 1.99, 95% CI 1.46-2.72), with an interaction term (HR 0.51, 95% CI 0.37-0.71) in multivariable models. CONCLUSIONS: Our findings suggest that (1) frailty is not a good discriminator of prognosis in COVID-19 and (2) pathways to mortality may differ in fitter compared with frailer older patients.
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Eur+Geriatr+Med 2020 ; 11 (5): 851-855
