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10.1016/j.intimp.2020.106738

http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.106738
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suck abstract from ncbi


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pmid32683296      Int+Immunopharmacol 2020 ; 86 (ä): 106738
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  • Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review #MMPMID32683296
  • Noorimotlagh Z; Karami C; Mirzaee SA; Kaffashian M; Mami S; Azizi M
  • Int Immunopharmacol 2020[Sep]; 86 (ä): 106738 PMID32683296show ga
  • The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus.
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Computational Biology[MESH]
  • |Coronavirus Infections/epidemiology/immunology/*prevention & control/virology[MESH]
  • |Drug Development/methods[MESH]
  • |Epitopes, B-Lymphocyte/immunology[MESH]
  • |Epitopes, T-Lymphocyte/immunology[MESH]
  • |Humans[MESH]
  • |Nucleocapsid Proteins/*immunology[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/epidemiology/immunology/*prevention & control/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]
  • |Vaccines, Subunit/immunology/therapeutic use[MESH]


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