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10.1016/j.bbi.2020.07.014

http://scihub22266oqcxt.onion/10.1016/j.bbi.2020.07.014
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32682993!7366124!32682993
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suck abstract from ncbi


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pmid32682993      Brain+Behav+Immun 2020 ; 89 (ä): 543-554
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  • Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review #MMPMID32682993
  • Egbert AR; Cankurtaran S; Karpiak S
  • Brain Behav Immun 2020[Oct]; 89 (ä): 543-554 PMID32682993show ga
  • OBJECTIVE: This systematic review aimed to synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase. METHODS: We performed systematic literature search via PubMed, Google Scholar and ScienceDirect on articles published between January 1 and July 05, 2020, using the following strategy and key words: ((covid[Title/Abstract]) OR (sars-cov-2[Title/Abstract]) OR (coronavirus[Title/Abstract])) AND (brain[Title/Abstract]). A total of 286 non-duplicate matches were screened for original contributions reporting brain imaging data related to SARS-Cov-2 presentation in adults. RESULTS: The selection criteria were met by 26 articles (including 21 case reports, and 5 cohort studies). The data analysis in a total of 361 patients revealed that brain abnormalities were noted in 124/361 (34%) reviewed cases. Neurologic symptoms were the primary reason for referral for neuroimaging across the studies. Modalities included CT (-angiogram, -perfusion, -venogram), EEG, MRI (-angiogram, functional), and PET. The most frequently reported brain abnormalities were brain white matter (WM) hyperintensities on MRI 66/124 (53% affected cases) and hypodensities on CT (additional 23% affected cases), followed by microhemorrhages, hemorrhages and infarcts, while other types were found in <5% affected cases. WM abnormalities were most frequently noted in bilateral anterior and posterior cerebral WM (50% affected cases). CONCLUSION: About a third of acute/subacute COVID-19 patients referred for neuroimaging show brain abnormalities suggestive of COVID-19-related etiology. The predominant neuroimaging features were diffuse cerebral WM hypodensities / hyperintensities attributable to leukoencephalopathy, leukoaraiosis or rarefield WM.
  • |Acute Disease[MESH]
  • |Betacoronavirus[MESH]
  • |Brain/*diagnostic imaging[MESH]
  • |COVID-19[MESH]
  • |Cerebral Angiography[MESH]
  • |Cerebral Hemorrhage/*diagnostic imaging/etiology[MESH]
  • |Cerebral Infarction/*diagnostic imaging/etiology[MESH]
  • |Computed Tomography Angiography[MESH]
  • |Coronavirus Infections/complications/*diagnostic imaging[MESH]
  • |Electroencephalography[MESH]
  • |Humans[MESH]
  • |Leukoaraiosis/*diagnostic imaging/etiology[MESH]
  • |Leukoencephalopathies/*diagnostic imaging/etiology[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*diagnostic imaging[MESH]
  • |Positron-Emission Tomography[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]


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