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10.1016/S0140-6736(20)31305-2 http://scihub22266oqcxt.onion/10.1016/S0140-6736(20)31305-2 32682491!7365650!32682491     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet 2020 ; 396 (10247): 320-332 Nephropedia Template TP {{tp|p=32682491|t=2020. Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series |pdf=|usr=}}{{32682491}} gab.com Text Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series JO: Lancet http://www.kidney.de/pget.php?&tw=1&pmid=32682491 #FOAvip BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. We aimed to provide a clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue tropism. METHODS: In this case series, patients with a positive antemortem or post-mortem SARS-CoV-2 result were considered eligible for enrolment. Post-mortem examinations were done on 14 people who died with COVID-19 at the King County Medical Examiner's Office (Seattle, WA, USA) and Snohomish County Medical Examiner's Office (Everett, WA, USA) in negative-pressure isolation suites during February and March, 2020. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry, electron microscopy, and quantitative RT-PCR. FINDINGS: The median age of our cohort was 73.5 years (range 42-84; IQR 67.5-77.25). All patients had clinically significant comorbidities, the most common being hypertension, chronic kidney disease, obstructive sleep apnoea, and metabolic disease including diabetes and obesity. The major pulmonary finding was diffuse alveolar damage in the acute or organising phases, with five patients showing focal pulmonary microthrombi. Coronavirus-like particles were detected in the respiratory system, kidney, and gastrointestinal tract. Lymphocytic myocarditis was observed in one patient with viral RNA detected in the tissue. INTERPRETATION: The primary pathology observed in our cohort was diffuse alveolar damage, with virus located in the pneumocytes and tracheal epithelium. Microthrombi, where observed, were scarce and endotheliitis was not identified. Although other non-pulmonary organs showed susceptibility to infection, their contribution to the pathogenesis of SARS-CoV-2 infection requires further examination. FUNDING: None. Twit Text FOAVip Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series ????Lancet http://www.kidney.de/pget.php?&tw=1&pmid=32682491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32682491 #FOAvip English Wikipedia <ref>{{Cite pmid|32682491}}</ref> Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series #MMPMID32682491 Bradley BT; Maioli H; Johnston R; Chaudhry I; Fink SL; Xu H; Najafian B; Deutsch G; Lacy JM; Williams T; Yarid N; Marshall DA Lancet 2020[Aug]; 396 (10247): 320-332 PMID32682491show ga BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. We aimed to provide a clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue tropism. METHODS: In this case series, patients with a positive antemortem or post-mortem SARS-CoV-2 result were considered eligible for enrolment. Post-mortem examinations were done on 14 people who died with COVID-19 at the King County Medical Examiner's Office (Seattle, WA, USA) and Snohomish County Medical Examiner's Office (Everett, WA, USA) in negative-pressure isolation suites during February and March, 2020. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry, electron microscopy, and quantitative RT-PCR. FINDINGS: The median age of our cohort was 73.5 years (range 42-84; IQR 67.5-77.25). All patients had clinically significant comorbidities, the most common being hypertension, chronic kidney disease, obstructive sleep apnoea, and metabolic disease including diabetes and obesity. The major pulmonary finding was diffuse alveolar damage in the acute or organising phases, with five patients showing focal pulmonary microthrombi. Coronavirus-like particles were detected in the respiratory system, kidney, and gastrointestinal tract. Lymphocytic myocarditis was observed in one patient with viral RNA detected in the tissue. INTERPRETATION: The primary pathology observed in our cohort was diffuse alveolar damage, with virus located in the pneumocytes and tracheal epithelium. Microthrombi, where observed, were scarce and endotheliitis was not identified. Although other non-pulmonary organs showed susceptibility to infection, their contribution to the pathogenesis of SARS-CoV-2 infection requires further examination. FUNDING: None. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Alveolar Epithelial Cells/pathology/ultrastructure/virology[MESH] |Autopsy[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/*pathology[MESH] |Female[MESH] |Gastrointestinal Tract/pathology/ultrastructure/virology[MESH] |Heart/virology[MESH] |Humans[MESH] |Kidney/pathology/ultrastructure/virology[MESH] |Liver/pathology/ultrastructure/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Myocardium/pathology/ultrastructure[MESH] |Pandemics[MESH] |Pneumonia, Viral/epidemiology/*pathology[MESH] |Pulmonary Alveoli/pathology/ultrastructure[MESH] |Respiratory Mucosa/pathology/ultrastructure/virology[MESH] |SARS-CoV-2[MESH] |Spleen/pathology/ultrastructure/virology[MESH] |Thrombosis/pathology[MESH] |Trachea/pathology/ultrastructure/virology[MESH]Histopathology and ultrastructural findings of fatal COVID-19 infectio(epmc).pdf DeepDyve Pubget Overpricing