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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Turk+J+Med+Sci 2020 ; 50 (8): 1801-1809 Nephropedia Template TP
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COVID-19 experience of the major pandemic response center in the capital: results of the pandemic s first month in Turkey #MMPMID32682358
Guner R; Hasanoglu I; Kayaaslan B; Aypak A; Kaya Kalem A; Eser F; Ozdemir B; Saricaoglu EM; Ayhan M; Aybar Bilir Y; Ozkocak Turan I; Erdem D; Mutlu NM; Buzgan T; Dinc B; Akinci E
Turk J Med Sci 2020[Dec]; 50 (8): 1801-1809 PMID32682358show ga
BACKGROUND/AIM: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. MATERIALS AND METHODS: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. RESULTS: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. CONCLUSION: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.