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10.1016/j.psyneuen.2020.104801 http://scihub22266oqcxt.onion/10.1016/j.psyneuen.2020.104801 32682172!7348598!32682172     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Psychoneuroendocrinology 2020 ; 120 (ä): 104801 Nephropedia Template TP {{tp|p=32682172|t=2020. Circulating endocannabinoid concentrations in grieving adults |pdf=|usr=}}{{32682172}} gab.com Text Circulating endocannabinoid concentrations in grieving adults JO: Psychoneuroendocrinology http://www.kidney.de/pget.php?&tw=1&pmid=32682172 #FOAvip Bereavement is one of the most intense, distressing, and traumatic events an elderly person will experience. The symptom responses to bereavement vary, particularly during the first year. However, the neurobiology underlying the symptom variance in grief is poorly understood. The endocannabinoid signaling (ECS) system is stress-responsive; mounting evidence implicates the central ECS in psychopathology. The current study aimed to investigate the hypothesis that the ECS is abnormal in grief, using circulating eCB concentrations as a biomarker of central ECS. A predominantly older sample of grief participants, within 13 months following the death of a loved one, and healthy comparison (HC) participants were studied. Associations of circulating eCBs with symptom variance in grievers were also examined. A total of 61 (grief: n = 44; HC: n = 17) adults completed cross-sectional clinical assessments and a fasting blood draw. Assessments included the Inventory of Complicated Grief scale; the 17-item Hamilton Depression Rating Scale; and the Hamilton Anxiety scale. Serum eCB concentrations (i.e., N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) were quantified using isotope dilution, liquid chromatography-mass spectrometry. Relative to HC participants, grievers had significantly elevated serum AEA but similar 2-AG concentrations. In grievers, serum AEA concentrations were positively associated with depressive and anxiety symptoms, but only in those with low grief symptoms. These novel findings indicate that elevated circulating eCB concentrations are found following bereavement. The eCB signaling response varies based on the degree of grief severity. Circulating eCB measures may have the potential to serve as biomarkers of prolonged grief disorder. Twit Text FOAVip Circulating endocannabinoid concentrations in grieving adults ????Psychoneuroendocrinology http://www.kidney.de/pget.php?&tw=1&pmid=32682172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32682172 #FOAvip English Wikipedia <ref>{{Cite pmid|32682172}}</ref> Circulating endocannabinoid concentrations in grieving adults #MMPMID32682172 Harfmann EJ; McAuliffe TL; Larson ER; Claesges SA; Sauber G; Hillard CJ; Goveas JS Psychoneuroendocrinology 2020[Oct]; 120 (ä): 104801 PMID32682172show ga Bereavement is one of the most intense, distressing, and traumatic events an elderly person will experience. The symptom responses to bereavement vary, particularly during the first year. However, the neurobiology underlying the symptom variance in grief is poorly understood. The endocannabinoid signaling (ECS) system is stress-responsive; mounting evidence implicates the central ECS in psychopathology. The current study aimed to investigate the hypothesis that the ECS is abnormal in grief, using circulating eCB concentrations as a biomarker of central ECS. A predominantly older sample of grief participants, within 13 months following the death of a loved one, and healthy comparison (HC) participants were studied. Associations of circulating eCBs with symptom variance in grievers were also examined. A total of 61 (grief: n = 44; HC: n = 17) adults completed cross-sectional clinical assessments and a fasting blood draw. Assessments included the Inventory of Complicated Grief scale; the 17-item Hamilton Depression Rating Scale; and the Hamilton Anxiety scale. Serum eCB concentrations (i.e., N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) were quantified using isotope dilution, liquid chromatography-mass spectrometry. Relative to HC participants, grievers had significantly elevated serum AEA but similar 2-AG concentrations. In grievers, serum AEA concentrations were positively associated with depressive and anxiety symptoms, but only in those with low grief symptoms. These novel findings indicate that elevated circulating eCB concentrations are found following bereavement. The eCB signaling response varies based on the degree of grief severity. Circulating eCB measures may have the potential to serve as biomarkers of prolonged grief disorder. |*Grief[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Anxiety/metabolism/physiopathology[MESH] |Arachidonic Acids/analysis/blood[MESH] |Bereavement[MESH] |Biomarkers/blood[MESH] |Cross-Sectional Studies[MESH] |Depression/metabolism/physiopathology[MESH] |Endocannabinoids/*analysis/blood[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Circulating endocannabinoid concentrations in grieving adults (epmc).pdf DeepDyve Pubget Overpricing