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10.1016/j.niox.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.niox.2020.07.003
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32681986!7362842!32681986
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suck abstract from ncbi


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pmid32681986      Nitric+Oxide 2020 ; 103 (ä): 4-8
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  • Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19 #MMPMID32681986
  • Adusumilli NC; Zhang D; Friedman JM; Friedman AJ
  • Nitric Oxide 2020[Oct]; 103 (ä): 4-8 PMID32681986show ga
  • The ongoing outbreak of COVID-19 has quickly become a daunting challenge to global health. In the absence of targeted therapy and a reported 5.5% case fatality rate in the United States, treatments preventing rapid cardiopulmonary failure are urgently needed. Clinical features, pathology and homology to better understood pathogens suggest that uncontrolled inflammation and a cytokine storm likely drive COVID-19's unrelenting disease process. Interventions that are protective against acute lung injury and ARDS can play a critical role for patients and health systems during this pandemic. Nitric oxide is an antimicrobial and anti-inflammatory molecule with key roles in pulmonary vascular function in the context of viral infections and other pulmonary disease states. This article reviews the rationale for exogenous nitric oxide use for the pathogenesis of COVID-19 and highlights its potential for contributing to better clinical outcomes and alleviating the rapidly rising strain on healthcare capacity.
  • |Administration, Inhalation[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/*prevention & control[MESH]
  • |Humans[MESH]
  • |Nitric Oxide Donors/therapeutic use[MESH]
  • |Nitric Oxide/administration & dosage/*therapeutic use[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*drug therapy/*prevention & control[MESH]


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