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10.1016/j.cca.2020.07.018

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.07.018
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32681933!7363604!32681933
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suck abstract from ncbi


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pmid32681933      Clin+Chim+Acta 2020 ; 510 (ä): 186-190
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  • The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19 #MMPMID32681933
  • Deng P; Ke Z; Ying B; Qiao B; Yuan L
  • Clin Chim Acta 2020[Nov]; 510 (ä): 186-190 PMID32681933show ga
  • OBJECTIVE: The aim of this study was to systematically and comprehensively evaluate the diagnostic and prognostic value of myocardial injury biomarkers in COVID-19 patients. METHODS: This is a retrospective cohort study of confirmed COVID-19 patients that were admitted to the Renmin Hospital of Wuhan University from January 30, 2020 to February 15, 2020. RESULTS: Receiver operating characteristic (ROC) curve analysis demonstrated that cTnI-ultra had the highest area under the curve (AUC) at 0.855, with a sensitivity of 67.3% and a specificity of 88.7% for the prediction of in-hospital mortality. Patients with higher troponin I-ultra (cTnI-ultra), creatinine kinase-myocardial band (CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were associated with higher mortality, compared to those who lower levels. The multivariable cox regression indicated that age (hazard ratio (HR) 3.450, 95% confidence interval (CI) 1.627-7.314, P = 0.001), coronary heart disease (HR 1.855, 95% CI 1.006-3.421; P = 0.048), elevated cTnI-ultra (HR 3.083, 95% CI 1.616-5.883, P = 0.001), elevated CK-MB (HR 2.907, 95% CI 1.233-6.854; P = 0.015), and elevated NT-proBNP (HR 5.776, 95% CI 2.272-14.682; P < 0.001) were associated with in-hospital mortality. CONCLUSIONS: cTnI-ultra might be the best predictor of in-hospital mortality among myocardial injury biomarkers. Elevated cTnI-ultra, CK-MB, and NT-proBNP were independent biomarkers of the mortality in COVID-19 patients.
  • |*Hospitalization[MESH]
  • |Aged[MESH]
  • |Biomarkers/metabolism[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*complications/*diagnosis/metabolism/mortality[MESH]
  • |Female[MESH]
  • |Heart Injuries/*complications/*metabolism[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*diagnosis/metabolism/mortality[MESH]
  • |ROC Curve[MESH]


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