Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s12026-020-09145-5 http://scihub22266oqcxt.onion/10.1007/s12026-020-09145-5 32681497!7366458!32681497     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Res 2020 ; 68 (4): 213-224 Nephropedia Template TP {{tp|p=32681497|t=2020. COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy |pdf=|usr=}}{{32681497}} gab.com Text COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy JO: Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=32681497 #FOAvip SARS-CoV-2 infection is characterized by a protean clinical picture that can range from asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display a severe pulmonary involvement and develop neutrophilia, lymphopenia, and strikingly elevated levels of IL-6. There is an over-exuberant cytokine release with hyperferritinemia leading to the idea that COVID-19 is part of the hyperferritinemic syndrome spectrum. Indeed, very high levels of ferritin can occur in other diseases including hemophagocytic lymphohistiocytosis, macrophage activation syndrome, adult-onset Still's disease, catastrophic antiphospholipid syndrome and septic shock. Numerous studies have demonstrated the immunomodulatory effects of ferritin and its association with mortality and sustained inflammatory process. High levels of free iron are harmful in tissues, especially through the redox damage that can lead to fibrosis. Iron chelation represents a pillar in the treatment of iron overload. In addition, it was proven to have an anti-viral and anti-fibrotic activity. Herein, we analyse the pathogenic role of ferritin and iron during SARS-CoV-2 infection and propose iron depletion therapy as a novel therapeutic approach in the COVID-19 pandemic. Twit Text FOAVip COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy ????Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=32681497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32681497 #FOAvip English Wikipedia <ref>{{Cite pmid|32681497}}</ref> COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy #MMPMID32681497 Perricone C; Bartoloni E; Bursi R; Cafaro G; Guidelli GM; Shoenfeld Y; Gerli R Immunol Res 2020[Aug]; 68 (4): 213-224 PMID32681497show ga SARS-CoV-2 infection is characterized by a protean clinical picture that can range from asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display a severe pulmonary involvement and develop neutrophilia, lymphopenia, and strikingly elevated levels of IL-6. There is an over-exuberant cytokine release with hyperferritinemia leading to the idea that COVID-19 is part of the hyperferritinemic syndrome spectrum. Indeed, very high levels of ferritin can occur in other diseases including hemophagocytic lymphohistiocytosis, macrophage activation syndrome, adult-onset Still's disease, catastrophic antiphospholipid syndrome and septic shock. Numerous studies have demonstrated the immunomodulatory effects of ferritin and its association with mortality and sustained inflammatory process. High levels of free iron are harmful in tissues, especially through the redox damage that can lead to fibrosis. Iron chelation represents a pillar in the treatment of iron overload. In addition, it was proven to have an anti-viral and anti-fibrotic activity. Herein, we analyse the pathogenic role of ferritin and iron during SARS-CoV-2 infection and propose iron depletion therapy as a novel therapeutic approach in the COVID-19 pandemic. |*Coronavirus Infections/blood/drug therapy/epidemiology[MESH] |*Iron Overload/blood/drug therapy/epidemiology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/drug therapy/epidemiology[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Ferritins/*blood[MESH] |Humans[MESH] |Iron Chelating Agents/*therapeutic use[MESH] |Iron/*blood[MESH]COVID-19 as part of the hyperferritinemic syndromes: the role of iron (epmc).pdf DeepDyve Pubget Overpricing