Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-020-17371-6 http://scihub22266oqcxt.onion/10.1038/s41467-020-17371-6 32681106!7367865!32681106     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3618 Nephropedia Template TP {{tp|p=32681106|t=2020. Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein |pdf=|usr=}}{{32681106}} gab.com Text Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32681106 #FOAvip Global emergencies caused by the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2 significantly endanger human health. The spike (S) glycoprotein is the key antigen and its conserved S2 subunit contributes to viral entry by mediating host-viral membrane fusion. However, structural information of the post-fusion S2 from these highly pathogenic human-infecting coronaviruses is still lacking. We used single-particle cryo-electron microscopy to show that the post-fusion SARS-CoV S2 forms a further rotated HR1-HR2 six-helix bundle and a tightly bound linker region upstream of the HR2 motif. The structures of pre- and post-fusion SARS-CoV S glycoprotein dramatically differ, resembling that of the Mouse hepatitis virus (MHV) and other class I viral fusion proteins. This structure suggests potential targets for the development of vaccines and therapies against a wide range of SARS-like coronaviruses. Twit Text FOAVip Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32681106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32681106 #FOAvip English Wikipedia <ref>{{Cite pmid|32681106}}</ref> Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein #MMPMID32681106 Fan X; Cao D; Kong L; Zhang X Nat Commun 2020[Jul]; 11 (1): 3618 PMID32681106show ga Global emergencies caused by the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2 significantly endanger human health. The spike (S) glycoprotein is the key antigen and its conserved S2 subunit contributes to viral entry by mediating host-viral membrane fusion. However, structural information of the post-fusion S2 from these highly pathogenic human-infecting coronaviruses is still lacking. We used single-particle cryo-electron microscopy to show that the post-fusion SARS-CoV S2 forms a further rotated HR1-HR2 six-helix bundle and a tightly bound linker region upstream of the HR2 motif. The structures of pre- and post-fusion SARS-CoV S glycoprotein dramatically differ, resembling that of the Mouse hepatitis virus (MHV) and other class I viral fusion proteins. This structure suggests potential targets for the development of vaccines and therapies against a wide range of SARS-like coronaviruses. |Amino Acid Motifs[MESH] |Betacoronavirus/*chemistry/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/virology[MESH] |Coronavirus/chemistry/classification[MESH] |Cryoelectron Microscopy[MESH] |Humans[MESH] |Membrane Fusion[MESH] |Models, Molecular[MESH] |Pandemics[MESH] |Pneumonia, Viral/virology[MESH] |Protein Conformation[MESH] |Protein Multimerization[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*chemistry[MESH]Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike gl(epmc).pdf DeepDyve Pubget Overpricing