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10.4049/jimmunol.2000642

http://scihub22266oqcxt.onion/10.4049/jimmunol.2000642
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32680957!ä!32680957

suck abstract from ncbi


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pmid32680957      J+Immunol 2020 ; 205 (5): 1198-1206
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  • SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production #MMPMID32680957
  • Franco R; Rivas-Santisteban R; Serrano-Marin J; Rodriguez-Perez AI; Labandeira-Garcia JL; Navarro G
  • J Immunol 2020[Sep]; 205 (5): 1198-1206 PMID32680957show ga
  • Fever in infections correlates with inflammation, macrophage infiltration into the affected organ, macrophage activation, and release of cytokines involved in immune response, hematopoiesis, and homeostatic processes. Angiotensin-converting enzyme 2 (ACE2) is the canonical cell surface receptor for SARS-CoV-2. ACE2 together with angiotensin receptor types 1 and 2 and ACE2 are components of the renin-angiotensin system (RAS). Exacerbated production of cytokines, mainly IL-6, points to macrophages as key to understand differential COVID-19 severity. SARS-CoV-2 may modulate macrophage-mediated inflammation events by altering the balance between angiotensin II, which activates angiotensin receptor types 1 and 2, and angiotensin 1-7 and alamandine, which activate MAS proto-oncogene and MAS-related D receptors, respectively. In addition to macrophages, lung cells express RAS components; also, some lung cells are able to produce IL-6. Addressing how SARS-CoV-2 unbalances RAS functionality via ACE2 will help design therapies to attenuate a COVID-19-related cytokine storm.
  • |*Renin-Angiotensin System[MESH]
  • |Angiotensin I/metabolism[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/immunology/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology/virology[MESH]
  • |Humans[MESH]
  • |Inflammation/immunology[MESH]
  • |Interleukin-6/*biosynthesis[MESH]
  • |Macrophages/immunology[MESH]
  • |Pandemics[MESH]
  • |Peptide Fragments/metabolism[MESH]
  • |Peptidyl-Dipeptidase A/*metabolism[MESH]
  • |Pneumonia, Viral/*immunology/virology[MESH]
  • |Proto-Oncogene Mas[MESH]
  • |Proto-Oncogene Proteins/metabolism[MESH]
  • |Receptor, Angiotensin, Type 1/metabolism[MESH]
  • |Receptor, Angiotensin, Type 2/metabolism[MESH]
  • |Receptors, G-Protein-Coupled/metabolism[MESH]
  • |Receptors, Virus/metabolism[MESH]


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