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10.1212/WNL.0000000000010112 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000010112 32680942!ä!32680942 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2020 ; 95 (13): e1868-e1882 Nephropedia Template TP {{tp|p=32680942|t=2020. Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study |pdf=|usr=}}{{32680942}} gab.com Text Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=32680942 #FOAvip OBJECTIVE: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. METHODS: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. RESULTS: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome (p = 0.006) and more frequently had corticospinal tract signs (p = 0.02). Patients with encephalitis were younger (p = 0.007), whereas agitation was more frequent for patients with leptomeningeal enhancement (p = 0.009). CONCLUSIONS: Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF. CLINICALTRIALSGOV IDENTIFIER: NCT04368390. Twit Text FOAVip Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=32680942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32680942 #FOAvip English Wikipedia <ref>{{Cite pmid|32680942}}</ref> Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study #MMPMID32680942 Kremer S; Lersy F; Anheim M; Merdji H; Schenck M; Oesterle H; Bolognini F; Messie J; Khalil A; Gaudemer A; Carre S; Alleg M; Lecocq C; Schmitt E; Anxionnat R; Zhu F; Jager L; Nesser P; Mba YT; Hmeydia G; Benzakoun J; Oppenheim C; Ferre JC; Maamar A; Carsin-Nicol B; Comby PO; Ricolfi F; Thouant P; Boutet C; Fabre X; Forestier G; de Beaurepaire I; Bornet G; Desal H; Boulouis G; Berge J; Kazemi A; Pyatigorskaya N; Lecler A; Saleme S; Edjlali-Goujon M; Kerleroux B; Constans JM; Zorn PE; Mathieu M; Baloglu S; Ardellier FD; Willaume T; Brisset JC; Caillard S; Collange O; Mertes PM; Schneider F; Fafi-Kremer S; Ohana M; Meziani F; Meyer N; Helms J; Cotton F Neurology 2020[Sep]; 95 (13): e1868-e1882 PMID32680942show ga OBJECTIVE: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. METHODS: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. RESULTS: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome (p = 0.006) and more frequently had corticospinal tract signs (p = 0.02). Patients with encephalitis were younger (p = 0.007), whereas agitation was more frequent for patients with leptomeningeal enhancement (p = 0.009). CONCLUSIONS: Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF. CLINICALTRIALSGOV IDENTIFIER: NCT04368390. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |Brain Ischemia/*diagnostic imaging/physiopathology[MESH] |Brain/*diagnostic imaging[MESH] |COVID-19[MESH] |Confusion/physiopathology[MESH] |Consciousness Disorders/physiopathology[MESH] |Coronavirus Infections/*diagnostic imaging/physiopathology[MESH] |Encephalitis/diagnostic imaging/physiopathology[MESH] |Female[MESH] |France[MESH] |Headache/physiopathology[MESH] |Humans[MESH] |Magnetic Resonance Imaging[MESH] |Male[MESH] |Meningitis/diagnostic imaging/physiopathology[MESH] |Meningoencephalitis/*diagnostic imaging/physiopathology[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnostic imaging/physiopathology[MESH] |Psychomotor Agitation/physiopathology[MESH] |Pyramidal Tracts/diagnostic imaging/physiopathology[MESH] |Respiratory Distress Syndrome/physiopathology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Stroke/*diagnostic imaging/physiopathology[MESH]Neurologic and neuroimaging findings in patients with COVID-19: A retr(epmc).pdf DeepDyve Pubget Overpricing