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10.1111/bjh.17034

http://scihub22266oqcxt.onion/10.1111/bjh.17034
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32679621!7405050!32679621
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suck abstract from ncbi


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pmid32679621      Br+J+Haematol 2020 ; 191 (2): 207-211
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  • Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients #MMPMID32679621
  • Bellesi S; Metafuni E; Hohaus S; Maiolo E; Marchionni F; D'Innocenzo S; La Sorda M; Ferraironi M; Ramundo F; Fantoni M; Murri R; Cingolani A; Sica S; Gasbarrini A; Sanguinetti M; Chiusolo P; De Stefano V
  • Br J Haematol 2020[Oct]; 191 (2): 207-211 PMID32679621show ga
  • A low count of CD4(+) and CD8(+) lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4(+) T and CD8(+) T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4(+) cells correlated with lower CD4(+) counts. A higher expression of CD95 in CD4(+) and CD8(+) lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Aging/blood/immunology[MESH]
  • |Apoptosis[MESH]
  • |CD4-Positive T-Lymphocytes/*chemistry[MESH]
  • |CD8-Positive T-Lymphocytes/*chemistry[MESH]
  • |COVID-19/blood/complications/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocyte Subsets/*chemistry[MESH]
  • |Lymphopenia/*etiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prognosis[MESH]
  • |Programmed Cell Death 1 Receptor/*blood[MESH]
  • |SARS-CoV-2[MESH]


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