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10.1002/biot.202000100 http://scihub22266oqcxt.onion/10.1002/biot.202000100 32679620!ä!32679620 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biotechnol+J 2020 ; 15 (12): e2000100 Nephropedia Template TP {{tp|p=32679620|t=2020. Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response |pdf=|usr=}}{{32679620}} gab.com Text Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response JO: Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=32679620 #FOAvip Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens. Twit Text FOAVip Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response ????Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=32679620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32679620 #FOAvip English Wikipedia <ref>{{Cite pmid|32679620}}</ref> Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response #MMPMID32679620 Demircan MB; Tohumeken S; Gunduz N; Khalily MA; Tekinay T; Guler MO; Tekinay AB Biotechnol J 2020[Dec]; 15 (12): e2000100 PMID32679620show ga Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens. |Adjuvants, Immunologic/administration & dosage/*chemistry[MESH] |Animals[MESH] |Antigen Presentation[MESH] |Antigen-Presenting Cells/cytology/immunology[MESH] |Antigens/administration & dosage/chemistry[MESH] |Biocompatible Materials/chemistry[MESH] |Biotechnology[MESH] |Biotin/analogs & derivatives[MESH] |Cytokines/metabolism[MESH] |Drug Design[MESH] |Immunity, Cellular[MESH] |Immunity, Humoral[MESH] |In Vitro Techniques[MESH] |Male[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Nanofibers/administration & dosage/*chemistry/ultrastructure[MESH] |Ovalbumin/administration & dosage/immunology[MESH] |Peptides/administration & dosage/*chemistry/*immunology[MESH]Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant (epmc).pdf DeepDyve Pubget Overpricing