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10.1016/j.mehy.2020.110018 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110018 32679422!7834647!32679422     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32679422&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 143 (ä): 110018 Nephropedia Template TP {{tp|p=32679422|t=2020. Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis?|pdf=|usr=}}{{32679422}} gab.com Text Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32679422 #FOAvip Coronaviruses (CoV), discovered after 1960, caused human life-threatening outbreaks. SARS-CoV2, which appeared in Wuhan, China in December 2019, causing Severe Acute Respiratory Syndrome and has different features than other coronaviruses, has been determined and the disease caused by the virus has been called "Coronavirus Disease-2019" (COVID-19). This disease activates both the natural and acquired immune system. The cytokin storm, in which blood levels of proinflammatory cytokines are detected excessively high is developing and the uncontrolled inflammatory response causes local and systemic tissue damages. Although a spesific drug has not been found yet, the medications currently in use for other indications, whose pharmacokinetic- pharmacodynamic properties and toxic doses are already known; are included in the treatment practice of COVID-19. These drugs affect the entry of the virus into the cell and its intracellular distribution. They also have anti-inflammatory and immunomodulating effects too. Therefore, we think that Proton Pump Inhibitors (PPI's) with similar mechanisms of action may also be involved in COVID-19 treatment and prophylaxis. Twit Text FOAVip Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32679422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32679422 #FOAvip English Wikipedia <ref>{{Cite pmid|32679422}}</ref> Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis? #MMPMID32679422 Tastemur S; Ataseven H Med Hypotheses 2020[Oct]; 143 (ä): 110018 PMID32679422show ga Coronaviruses (CoV), discovered after 1960, caused human life-threatening outbreaks. SARS-CoV2, which appeared in Wuhan, China in December 2019, causing Severe Acute Respiratory Syndrome and has different features than other coronaviruses, has been determined and the disease caused by the virus has been called "Coronavirus Disease-2019" (COVID-19). This disease activates both the natural and acquired immune system. The cytokin storm, in which blood levels of proinflammatory cytokines are detected excessively high is developing and the uncontrolled inflammatory response causes local and systemic tissue damages. Although a spesific drug has not been found yet, the medications currently in use for other indications, whose pharmacokinetic- pharmacodynamic properties and toxic doses are already known; are included in the treatment practice of COVID-19. These drugs affect the entry of the virus into the cell and its intracellular distribution. They also have anti-inflammatory and immunomodulating effects too. Therefore, we think that Proton Pump Inhibitors (PPI's) with similar mechanisms of action may also be involved in COVID-19 treatment and prophylaxis. |*Betacoronavirus/drug effects/physiology[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/epidemiology/*prevention & control[MESH] |Drug Repositioning[MESH] |Host Microbial Interactions/drug effects/physiology[MESH] |Humans[MESH] |Hydrogen-Ion Concentration[MESH] |Hydroxychloroquine/therapeutic use[MESH] |Models, Biological[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/*drug therapy/epidemiology/*prevention & control[MESH] |Proton Pump Inhibitors/*therapeutic use[MESH] |SARS-CoV-2[MESH]Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and(epmc).pdf DeepDyve Pubget Overpricing