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10.1016/j.ijbiomac.2020.07.106 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2020.07.106 32679328!7358770!32679328     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2020 ; 164 (ä): 331-343 Nephropedia Template TP {{tp|p=32679328|t=2020. Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines |pdf=|usr=}}{{32679328}} gab.com Text Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32679328 #FOAvip Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002-2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines. Twit Text FOAVip Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32679328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32679328 #FOAvip English Wikipedia <ref>{{Cite pmid|32679328}}</ref> Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines #MMPMID32679328 Chen X; Han W; Wang G; Zhao X Int J Biol Macromol 2020[Dec]; 164 (ä): 331-343 PMID32679328show ga Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002-2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines. |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology/therapeutic use[MESH] |Betacoronavirus/chemistry/immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/*drug therapy/immunology/*prevention & control[MESH] |Coronavirus/*drug effects/immunology[MESH] |Humans[MESH] |Models, Molecular[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/drug therapy/prevention & control[MESH] |Polysaccharides/chemistry/*pharmacology/therapeutic use[MESH] |SARS-CoV-2[MESH]Application prospect of polysaccharides in the development of anti-nov(epmc).pdf DeepDyve Pubget Overpricing