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10.1016/j.jacc.2020.07.022 http://scihub22266oqcxt.onion/10.1016/j.jacc.2020.07.022 32679155!7833185!32679155     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Coll+Cardiol 2020 ; 76 (10): 1168-1176 Nephropedia Template TP {{tp|p=32679155|t=2020. High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segment Elevation Myocardial Infarction |pdf=|usr=}}{{32679155}} gab.com Text High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segment Elevation Myocardial Infarction JO: J Am Coll Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=32679155 #FOAvip BACKGROUND: Coronavirus disease-2019 (COVID-19) is thought to predispose patients to thrombotic disease. To date there are few reports of ST-segment elevation myocardial infarction (STEMI) caused by type 1 myocardial infarction in patients with COVID-19. OBJECTIVES: The aim of this study was to describe the demographic, angiographic, and procedural characteristics alongside clinical outcomes of consecutive cases of COVID-19-positive patients with STEMI compared with COVID-19-negative patients. METHODS: This was a single-center, observational study of 115 consecutive patients admitted with confirmed STEMI treated with primary percutaneous coronary intervention at Barts Heart Centre between March 1, 2020, and May 20, 2020. RESULTS: Patients with STEMI presenting with concurrent COVID-19 infection had higher levels of troponin T and lower lymphocyte count, but elevated D-dimer and C-reactive protein. There were significantly higher rates of multivessel thrombosis, stent thrombosis, higher modified thrombus grade post first device with consequently higher use of glycoprotein IIb/IIIa inhibitors and thrombus aspiration. Myocardial blush grade and left ventricular function were significantly lower in patients with COVID-19 with STEMI. Higher doses of heparin to achieve therapeutic activated clotting times were also noted. Importantly, patients with STEMI presenting with COVID-19 infection had a longer in-patient admission and higher rates of intensive care admission. CONCLUSIONS: In patients presenting with STEMI and concurrent COVID-19 infection, there is a strong signal toward higher thrombus burden and poorer outcomes. This supports the need for establishing COVID-19 status in all STEMI cases. Further work is required to understand the mechanism of increased thrombosis and the benefit of aggressive antithrombotic therapy in selected cases. Twit Text FOAVip High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segment Elevation Myocardial Infarction ????J Am Coll Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=32679155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32679155 #FOAvip English Wikipedia <ref>{{Cite pmid|32679155}}</ref> High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segment Elevation Myocardial Infarction #MMPMID32679155 Choudry FA; Hamshere SM; Rathod KS; Akhtar MM; Archbold RA; Guttmann OP; Woldman S; Jain AK; Knight CJ; Baumbach A; Mathur A; Jones DA J Am Coll Cardiol 2020[Sep]; 76 (10): 1168-1176 PMID32679155show ga BACKGROUND: Coronavirus disease-2019 (COVID-19) is thought to predispose patients to thrombotic disease. To date there are few reports of ST-segment elevation myocardial infarction (STEMI) caused by type 1 myocardial infarction in patients with COVID-19. OBJECTIVES: The aim of this study was to describe the demographic, angiographic, and procedural characteristics alongside clinical outcomes of consecutive cases of COVID-19-positive patients with STEMI compared with COVID-19-negative patients. METHODS: This was a single-center, observational study of 115 consecutive patients admitted with confirmed STEMI treated with primary percutaneous coronary intervention at Barts Heart Centre between March 1, 2020, and May 20, 2020. RESULTS: Patients with STEMI presenting with concurrent COVID-19 infection had higher levels of troponin T and lower lymphocyte count, but elevated D-dimer and C-reactive protein. There were significantly higher rates of multivessel thrombosis, stent thrombosis, higher modified thrombus grade post first device with consequently higher use of glycoprotein IIb/IIIa inhibitors and thrombus aspiration. Myocardial blush grade and left ventricular function were significantly lower in patients with COVID-19 with STEMI. Higher doses of heparin to achieve therapeutic activated clotting times were also noted. Importantly, patients with STEMI presenting with COVID-19 infection had a longer in-patient admission and higher rates of intensive care admission. CONCLUSIONS: In patients presenting with STEMI and concurrent COVID-19 infection, there is a strong signal toward higher thrombus burden and poorer outcomes. This supports the need for establishing COVID-19 status in all STEMI cases. Further work is required to understand the mechanism of increased thrombosis and the benefit of aggressive antithrombotic therapy in selected cases. |*Coronary Thrombosis/blood/diagnosis/etiology[MESH] |*Coronavirus Infections/blood/complications/diagnosis/epidemiology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/complications/diagnosis/epidemiology[MESH] |*ST Elevation Myocardial Infarction/epidemiology/therapy[MESH] |Aged[MESH] |Betacoronavirus/isolation & purification[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronary Angiography/methods[MESH] |Female[MESH] |Fibrin Fibrinogen Degradation Products/analysis[MESH] |Fibrinolytic Agents/*therapeutic use[MESH] |Humans[MESH] |Lymphocyte Count/methods[MESH] |Male[MESH] |Middle Aged[MESH] |Outcome and Process Assessment, Health Care[MESH] |Patient Selection[MESH] |Percutaneous Coronary Intervention/*methods[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segm(epmc).pdf DeepDyve Pubget Overpricing