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10.1016/j.antiviral.2020.104878 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104878 32679055!7361110!32679055     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2020 ; 181 (ä): 104878 Nephropedia Template TP {{tp|p=32679055|t=2020. In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2 |pdf=|usr=}}{{32679055}} gab.com Text In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2 JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32679055 #FOAvip In response to the current pandemic caused by the novel SARS-CoV-2, identifying and validating effective therapeutic strategies is more than ever necessary. We evaluated the in vitro antiviral activities of a shortlist of compounds, known for their cellular broad-spectrum activities, together with drugs that are currently under evaluation in clinical trials for COVID-19 patients. We report the antiviral effect of remdesivir, lopinavir, chloroquine, umifenovir, berberine and cyclosporine A in Vero E6 cells model of SARS-CoV-2 infection, with estimated 50% inhibitory concentrations of 0.99, 5.2, 1.38, 3.5, 10.6 and 3 muM, respectively. Virus-directed plus host-directed drug combinations were also investigated. We report a strong antagonism between remdesivir and berberine, in contrast with remdesivir/diltiazem, for which we describe high levels of synergy, with mean Loewe synergy scores of 12 and peak values above 50. Combination of host-directed drugs with direct acting antivirals underscore further validation in more physiological models, yet they open up interesting avenues for the treatment of COVID-19. Twit Text FOAVip In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2 ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32679055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32679055 #FOAvip English Wikipedia <ref>{{Cite pmid|32679055}}</ref> In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2 #MMPMID32679055 Pizzorno A; Padey B; Dubois J; Julien T; Traversier A; Duliere V; Brun P; Lina B; Rosa-Calatrava M; Terrier O Antiviral Res 2020[Sep]; 181 (ä): 104878 PMID32679055show ga In response to the current pandemic caused by the novel SARS-CoV-2, identifying and validating effective therapeutic strategies is more than ever necessary. We evaluated the in vitro antiviral activities of a shortlist of compounds, known for their cellular broad-spectrum activities, together with drugs that are currently under evaluation in clinical trials for COVID-19 patients. We report the antiviral effect of remdesivir, lopinavir, chloroquine, umifenovir, berberine and cyclosporine A in Vero E6 cells model of SARS-CoV-2 infection, with estimated 50% inhibitory concentrations of 0.99, 5.2, 1.38, 3.5, 10.6 and 3 muM, respectively. Virus-directed plus host-directed drug combinations were also investigated. We report a strong antagonism between remdesivir and berberine, in contrast with remdesivir/diltiazem, for which we describe high levels of synergy, with mean Loewe synergy scores of 12 and peak values above 50. Combination of host-directed drugs with direct acting antivirals underscore further validation in more physiological models, yet they open up interesting avenues for the treatment of COVID-19. |*Drug Repositioning[MESH] |*Pandemics[MESH] |Adenosine Monophosphate/analogs & derivatives/pharmacology[MESH] |Alanine/analogs & derivatives/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Berberine/pharmacology[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chlorocebus aethiops[MESH] |Chloroquine/pharmacology[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Cyclosporine/pharmacology[MESH] |Drug Antagonism[MESH] |Drug Combinations[MESH] |Drug Synergism[MESH] |Humans[MESH] |Indoles/pharmacology[MESH] |Lopinavir/pharmacology[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |SARS-CoV-2[MESH]In vitro evaluation of antiviral activity of single and combined repur(epmc).pdf DeepDyve Pubget Overpricing