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10.1002/mus.27024

http://scihub22266oqcxt.onion/10.1002/mus.27024
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32678460!7405390!32678460
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suck abstract from ncbi


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pmid32678460      Muscle+Nerve 2020 ; 62 (4): 485-491
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  • COVID-19-associated Guillain-Barre syndrome: The early pandemic experience #MMPMID32678460
  • Caress JB; Castoro RJ; Simmons Z; Scelsa SN; Lewis RA; Ahlawat A; Narayanaswami P
  • Muscle Nerve 2020[Oct]; 62 (4): 485-491 PMID32678460show ga
  • Guillain-Barre syndrome (GBS) is an inflammatory polyradiculoneuropathy associated with numerous viral infections. Recently, there have been many case reports describing the association between coronavirus disease-2019 (COVID-19) and GBS, but much remains unknown about the strength of the association and the features of GBS in this setting. We reviewed 37 published cases of GBS associated with COVID-19 to summarize this information for clinicians and to determine whether a specific clinical or electrodiagnostic (EDx) pattern is emerging. The mean age (59 years), gender (65% male), and COVID-19 features appeared to reflect those of hospitalized COVID-19 patients early in the pandemic. The mean time from COVID-19 symptoms to GBS symptoms was 11 days. The clinical presentation and severity of these GBS cases was similar to those with non-COVID-19 GBS. The EDx pattern was considered demyelinating in approximately half of the cases. Cerebrospinal fluid, when assessed, demonstrated albuminocytologic dissociation in 76% of patients and was negative for severe acute respiratory distress syndrome-coronavirus-2 (SARS-CoV-2) in all cases. Serum antiganglioside antibodies were absent in 15 of 17 patients tested. Most patients were treated with a single course of intravenous immunoglobulin, and improvement was noted within 8 weeks in most cases. GBS-associated COVID-19 appears to be an uncommon condition with similar clinical and EDx patterns to GBS before the pandemic. Future studies should compare patients with COVID-19-associated GBS to those with contemporaneous non-COVID-19 GBS and determine whether the incidence of GBS is elevated in those with COVID-19.
  • |*Betacoronavirus[MESH]
  • |*Pandemics[MESH]
  • |Brain/*diagnostic imaging[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/epidemiology[MESH]
  • |Guillain-Barre Syndrome/diagnosis/*etiology/physiopathology[MESH]
  • |Humans[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Neural Conduction/*physiology[MESH]
  • |Pneumonia, Viral/*complications/epidemiology[MESH]
  • |SARS-CoV-2[MESH]


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