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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Med 2020 ; 217 (9): ä Nephropedia Template TP
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Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19 #MMPMID32678432
Koenig LM; Boehmer DFR; Metzger P; Schnurr M; Endres S; Rothenfusser S
J Exp Med 2020[Sep]; 217 (9): ä PMID32678432show ga
An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.