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10.1182/blood.2020007252 http://scihub22266oqcxt.onion/10.1182/blood.2020007252 32678428!7483437!32678428     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2020 ; 136 (11): 1330-1341 Nephropedia Template TP {{tp|p=32678428|t=2020. Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19 |pdf=|usr=}}{{32678428}} gab.com Text Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19 JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=32678428 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably increased morbidity and mortality around the world. A hypercoagulability state has been reported as a major pathologic event in COVID-19, and thromboembolic complications listed among life-threatening complications of the disease. Platelets are chief effector cells of hemostasis and pathological thrombosis. However, the participation of platelets in the pathogenesis of COVID-19 remains elusive. This report demonstrates that increased platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in patients presenting mild COVID-19 syndrome. In addition, exposure to plasma from severe COVID-19 patients increased the activation of control platelets ex vivo. In our cohort of COVID-19 patients admitted to the intensive care unit, platelet-monocyte interaction was strongly associated with tissue factor (TF) expression by the monocytes. Platelet activation and monocyte TF expression were associated with markers of coagulation exacerbation as fibrinogen and D-dimers, and were increased in patients requiring invasive mechanical ventilation or patients who evolved with in-hospital mortality. Finally, platelets from severe COVID-19 patients were able to induce TF expression ex vivo in monocytes from healthy volunteers, a phenomenon that was inhibited by platelet P-selectin neutralization or integrin alphaIIb/beta3 blocking with the aggregation inhibitor abciximab. Altogether, these data shed light on new pathological mechanisms involving platelet activation and platelet-dependent monocyte TF expression, which were associated with COVID-19 severity and mortality. Twit Text FOAVip Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19 ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=32678428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32678428 #FOAvip English Wikipedia <ref>{{Cite pmid|32678428}}</ref> Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19 #MMPMID32678428 Hottz ED; Azevedo-Quintanilha IG; Palhinha L; Teixeira L; Barreto EA; Pao CRR; Righy C; Franco S; Souza TML; Kurtz P; Bozza FA; Bozza PT Blood 2020[Sep]; 136 (11): 1330-1341 PMID32678428show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably increased morbidity and mortality around the world. A hypercoagulability state has been reported as a major pathologic event in COVID-19, and thromboembolic complications listed among life-threatening complications of the disease. Platelets are chief effector cells of hemostasis and pathological thrombosis. However, the participation of platelets in the pathogenesis of COVID-19 remains elusive. This report demonstrates that increased platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in patients presenting mild COVID-19 syndrome. In addition, exposure to plasma from severe COVID-19 patients increased the activation of control platelets ex vivo. In our cohort of COVID-19 patients admitted to the intensive care unit, platelet-monocyte interaction was strongly associated with tissue factor (TF) expression by the monocytes. Platelet activation and monocyte TF expression were associated with markers of coagulation exacerbation as fibrinogen and D-dimers, and were increased in patients requiring invasive mechanical ventilation or patients who evolved with in-hospital mortality. Finally, platelets from severe COVID-19 patients were able to induce TF expression ex vivo in monocytes from healthy volunteers, a phenomenon that was inhibited by platelet P-selectin neutralization or integrin alphaIIb/beta3 blocking with the aggregation inhibitor abciximab. Altogether, these data shed light on new pathological mechanisms involving platelet activation and platelet-dependent monocyte TF expression, which were associated with COVID-19 severity and mortality. |Adult[MESH] |Betacoronavirus/*immunology[MESH] |Biomarkers/metabolism[MESH] |Blood Coagulation Disorders/immunology/metabolism/*pathology/virology[MESH] |Blood Platelets/metabolism/*pathology/virology[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/*complications/immunology/metabolism/virology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/metabolism/*pathology/virology[MESH] |P-Selectin/metabolism[MESH] |Pandemics[MESH] |Platelet Activation[MESH] |Pneumonia, Viral/*complications/immunology/metabolism/virology[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH] |Survival Rate[MESH]Platelet activation and platelet-monocyte aggregate formation trigger (epmc).pdf DeepDyve Pubget Overpricing