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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Med 2020 ; 26 (9): 1405-1410 Nephropedia Template TP
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Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands #MMPMID32678356
Oude Munnink BB; Nieuwenhuijse DF; Stein M; O'Toole A; Haverkate M; Mollers M; Kamga SK; Schapendonk C; Pronk M; Lexmond P; van der Linden A; Bestebroer T; Chestakova I; Overmars RJ; van Nieuwkoop S; Molenkamp R; van der Eijk AA; GeurtsvanKessel C; Vennema H; Meijer A; Rambaut A; van Dissel J; Sikkema RS; Timen A; Koopmans M
Nat Med 2020[Sep]; 26 (9): 1405-1410 PMID32678356show ga
In late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China(1). The causative agent was identified as the species Severe acute respiratory syndrome-related coronavirus and was named SARS-CoV-2 (ref. (2)). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths(3). In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands.