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10.1186/s13613-020-00716-1 http://scihub22266oqcxt.onion/10.1186/s13613-020-00716-1 32676824!7364286!32676824     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32676824&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Ann+Intensive+Care 2020 ; 10 (1): 95 Nephropedia Template TP {{tp|p=32676824|t=2020. Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |pdf=|usr=}}{{32676824}} gab.com Text Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study JO: Ann Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=32676824 #FOAvip RATIONALE: COVID-19 ARDS could differ from typical forms of the syndrome. OBJECTIVE: Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. METHODS: Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1-4] day after intubation (median [IQR]). MEASUREMENTS AND MAIN RESULTS: Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1-44.7] mL/cmH(2)O and end-expiratory lung volume: 2100 [1721-2434] mL. Gas exchanges were characterized by hypercapnia 55 [44-62] mmHg, high physiological dead-space (V(D)/V(T)): 75 [69-85.5] % and ventilatory ratio (VR): 2.9 [2.2-3.4]. V(D)/V(T) and VR were significantly correlated: r(2) = 0.24, p = 0.014. No pulmonary embolism was suspected at the time of measurements. CECs and D-dimers were elevated as compared to normal values: 24 [12-46] cells per mL and 1483 [999-2217] ng/mL, respectively. CONCLUSIONS: We observed early in the course of COVID-19 ARDS high V(D)/V(T) in association with biological markers of endothelial damage and thrombosis. High V(D)/V(T) can be explained by high PEEP settings and added instrumental dead space, with a possible associated role of COVID-19-triggered pulmonary microvascular endothelial damage and microthrombotic process. Twit Text FOAVip Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study ????Ann Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=32676824 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32676824 #FOAvip English Wikipedia <ref>{{Cite pmid|32676824}}</ref> Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study #MMPMID32676824 Diehl JL; Peron N; Chocron R; Debuc B; Guerot E; Hauw-Berlemont C; Hermann B; Augy JL; Younan R; Novara A; Langlais J; Khider L; Gendron N; Goudot G; Fagon JF; Mirault T; Smadja DM Ann Intensive Care 2020[Jul]; 10 (1): 95 PMID32676824show ga RATIONALE: COVID-19 ARDS could differ from typical forms of the syndrome. OBJECTIVE: Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. METHODS: Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1-4] day after intubation (median [IQR]). MEASUREMENTS AND MAIN RESULTS: Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1-44.7] mL/cmH(2)O and end-expiratory lung volume: 2100 [1721-2434] mL. Gas exchanges were characterized by hypercapnia 55 [44-62] mmHg, high physiological dead-space (V(D)/V(T)): 75 [69-85.5] % and ventilatory ratio (VR): 2.9 [2.2-3.4]. V(D)/V(T) and VR were significantly correlated: r(2) = 0.24, p = 0.014. No pulmonary embolism was suspected at the time of measurements. CECs and D-dimers were elevated as compared to normal values: 24 [12-46] cells per mL and 1483 [999-2217] ng/mL, respectively. CONCLUSIONS: We observed early in the course of COVID-19 ARDS high V(D)/V(T) in association with biological markers of endothelial damage and thrombosis. High V(D)/V(T) can be explained by high PEEP settings and added instrumental dead space, with a possible associated role of COVID-19-triggered pulmonary microvascular endothelial damage and microthrombotic process. ?Respiratory mechanics and gas exchanges in the early course of COVID-1(epmc).pdf DeepDyve Pubget Overpricing