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10.1007/s00380-020-01671-4

http://scihub22266oqcxt.onion/10.1007/s00380-020-01671-4
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32676695!7364290!32676695
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suck abstract from ncbi


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pmid32676695      Heart+Vessels 2021 ; 36 (1): 115-120
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  • Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection #MMPMID32676695
  • Moschini L; Loffi M; Regazzoni V; Di Tano G; Gherbesi E; Danzi GB
  • Heart Vessels 2021[Jan]; 36 (1): 115-120 PMID32676695show ga
  • INTRODUCTION: Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc). OBJECTIVE: To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals. METHODS: At the beginning of COVID-19 pandemic patients admitted to our hospital were treated with the empiric association of HY/RD; one week later the therapeutic protocol was modified with the combination of HY/AZ. Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy. We prospectively enrolled 113 patients (61 in the HY/RD group-52 in the HY/AZ group). RESULTS: A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both). 23 patients (21.2%) had a QTc > 500 ms at 7 days. The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (>/= 440 ms for female and >/= 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001). One patient per group suffered a malignant ventricular arrhythmia. CONCLUSION: Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days. The risk of developing malignant arrhythmias remained relatively low when these drugs were administered for a limited period of time.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Anti-Bacterial Agents/adverse effects/therapeutic use[MESH]
  • |Azithromycin/*adverse effects/therapeutic use[MESH]
  • |COVID-19/epidemiology[MESH]
  • |Darunavir/*adverse effects/therapeutic use[MESH]
  • |Electrocardiography/*drug effects[MESH]
  • |Enzyme Inhibitors/therapeutic use[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Long QT Syndrome/*chemically induced/physiopathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Ritonavir/*adverse effects/therapeutic use[MESH]


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