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10.1101/2020.07.09.194027 http://scihub22266oqcxt.onion/10.1101/2020.07.09.194027 32676602!7359524!32676602     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32676602&cmd=llinks): Failed to open stream: HTTP request failed! 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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 (+) T cells |pdf=|usr=}}{{32676602}} gab.com Text Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 (+) T cells JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32676602 #FOAvip The molecular properties of CD8 (+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8 (+) T cells from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on whether the dominant CD8 (+) T cell response to SARS-CoV-2 was 'exhausted' or not. SARS-CoV-2-reactive cells in the exhausted subset were increased in frequency and displayed lesser cytotoxicity and inflammatory features in COVID-19 patients with mild compared to severe illness. In contrast, SARS-CoV-2-reactive cells in the non-exhausted subsets from patients with severe disease showed enrichment of transcripts linked to co-stimulation, pro-survival NF-kappaB signaling, and anti-apoptotic pathways, suggesting the generation of robust CD8 (+) T cell memory responses in patients with severe COVID-19 illness. CD8 (+) T cells reactive to influenza and respiratory syncytial virus from healthy subjects displayed polyfunctional features. Cells with such features were mostly absent in SARS-CoV-2 responsive cells from both COVID-19 patients and healthy controls non-exposed to SARS-CoV-2. Overall, our single-cell analysis revealed substantial diversity in the nature of CD8 (+) T cells responding to SARS-CoV-2. Twit Text FOAVip Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 (+) T cells ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32676602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32676602 #FOAvip English Wikipedia <ref>{{Cite pmid|32676602}}</ref> Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 (+) T cells #MMPMID32676602 Kusnadi A; Ramirez-Suastegui C; Fajardo V; Chee SJ; Meckiff BJ; Simon H; Pelosi E; Seumois G; Ay F; Vijayanand P; Ottensmeier CH bioRxiv 2020[Jul]; ä (ä): ä PMID32676602show ga The molecular properties of CD8 (+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8 (+) T cells from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on whether the dominant CD8 (+) T cell response to SARS-CoV-2 was 'exhausted' or not. SARS-CoV-2-reactive cells in the exhausted subset were increased in frequency and displayed lesser cytotoxicity and inflammatory features in COVID-19 patients with mild compared to severe illness. In contrast, SARS-CoV-2-reactive cells in the non-exhausted subsets from patients with severe disease showed enrichment of transcripts linked to co-stimulation, pro-survival NF-kappaB signaling, and anti-apoptotic pathways, suggesting the generation of robust CD8 (+) T cell memory responses in patients with severe COVID-19 illness. CD8 (+) T cells reactive to influenza and respiratory syncytial virus from healthy subjects displayed polyfunctional features. Cells with such features were mostly absent in SARS-CoV-2 responsive cells from both COVID-19 patients and healthy controls non-exposed to SARS-CoV-2. Overall, our single-cell analysis revealed substantial diversity in the nature of CD8 (+) T cells responding to SARS-CoV-2. äSeverely ill COVID-19 patients display augmented functional properties(epmc).pdf DeepDyve Pubget Overpricing