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10.1016/j.jamda.2020.06.013

http://scihub22266oqcxt.onion/10.1016/j.jamda.2020.06.013
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suck abstract from ncbi


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pmid32674822      J+Am+Med+Dir+Assoc 2020 ; 21 (7): 933-936
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  • Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak #MMPMID32674822
  • Blain H; Rolland Y; Tuaillon E; Giacosa N; Albrand M; Jaussent A; Benetos A; Miot S; Bousquet J
  • J Am Med Dir Assoc 2020[Jul]; 21 (7): 933-936 PMID32674822show ga
  • OBJECTIVE: To assess the American Testing Guidance for Nursing Homes (NHs)-updated May 19, 2020-with a new COVID-19 case. DESIGN: Case investigation. SETTING AND SUBJECTS: All 79 residents and 34 health care personnel (HCP) of an NH. METHODS: Seven days after identification of a COVID-19 resident, all residents and HCP underwent real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases, and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for enzyme-linked immunosorbent assay-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP. RESULTS: A total of 36 residents had a positive rRT-PCR at baseline and 2 at day 7. Six HCP had a positive rRT-PCR at baseline and 2 at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, 6 residents (16%) and 3 HCP (37%) were asymptomatic during the 14 days before testing. Twenty-five residents (92.3%) and all 8 HCP (100%) with a positive rRT-PCR developed IgG antibodies against SARS-CoV-2. Among the residents and HCP always having tested negative, 2 (5%) and 5 (11.5%), respectively, developed IgG antibodies against SARS-CoV-2. These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing. CONCLUSIONS AND IMPLICATIONS: This study shows the validity of the updated American Testing Guidance for Nursing Homes (NHs). It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative rRT-PCR testing can develop antibodies against SARS-CoV-2.
  • |Antibodies, Viral/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Clinical Laboratory Techniques/*methods/statistics & numerical data[MESH]
  • |Contact Tracing/methods/*statistics & numerical data[MESH]
  • |Coronavirus Infections/diagnosis/epidemiology[MESH]
  • |DNA, Viral/analysis[MESH]
  • |Disease Outbreaks/*prevention & control[MESH]
  • |Female[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Infectious Disease Transmission, Vertical/*prevention & control[MESH]
  • |Male[MESH]
  • |Nursing Homes/*organization & administration[MESH]
  • |Occupational Health/statistics & numerical data[MESH]
  • |Outcome Assessment, Health Care[MESH]
  • |Pandemics[MESH]
  • |Patient Safety/statistics & numerical data[MESH]
  • |Pneumonia, Viral/diagnosis/epidemiology[MESH]
  • |Real-Time Polymerase Chain Reaction/methods[MESH]
  • |Skilled Nursing Facilities/organization & administration[MESH]


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