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10.1016/j.mehy.2020.110089 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110089 32673940!7346812!32673940     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 143 (ä): 110089 Nephropedia Template TP {{tp|p=32673940|t=2020. EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions |pdf=|usr=}}{{32673940}} gab.com Text EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32673940 #FOAvip Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRIN, has been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attachment and entry into the host cell. Since one of the routes of entry for the virus is the oral cavity, it becomes imperative to percept oral comorbidities such oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper, it is proposed that OSCC, by the virtue of upregulation of EMMPRIN expression, increases the susceptibility to coronavirus disease (COVID-19). In turn, COVID-19 in OSCC patients causes exhaustion of EMMPRIN receptor due to binding with 'S' receptor leading to a downregulation of related carcinogenesis events. We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID-19 virus for the entry into the host cells. Apart from the anti-monoclonal antibody, it is recommended to explore the use of grape seed and skin containing mouthwash as an adjunct, which could also have anti EMMPRIN effects in patients with OSCC and OPMDs. Twit Text FOAVip EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32673940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32673940 #FOAvip English Wikipedia <ref>{{Cite pmid|32673940}}</ref> EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions #MMPMID32673940 Varadarajan S; Balaji TM; Sarode SC; Sarode GS; Sharma NK; Gondivkar S; Gadbail A; Patil S Med Hypotheses 2020[Oct]; 143 (ä): 110089 PMID32673940show ga Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRIN, has been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attachment and entry into the host cell. Since one of the routes of entry for the virus is the oral cavity, it becomes imperative to percept oral comorbidities such oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper, it is proposed that OSCC, by the virtue of upregulation of EMMPRIN expression, increases the susceptibility to coronavirus disease (COVID-19). In turn, COVID-19 in OSCC patients causes exhaustion of EMMPRIN receptor due to binding with 'S' receptor leading to a downregulation of related carcinogenesis events. We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID-19 virus for the entry into the host cells. Apart from the anti-monoclonal antibody, it is recommended to explore the use of grape seed and skin containing mouthwash as an adjunct, which could also have anti EMMPRIN effects in patients with OSCC and OPMDs. |*Gene Expression Regulation, Neoplastic[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Monoclonal[MESH] |Basigin/*metabolism[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Carcinoma, Squamous Cell/complications/metabolism[MESH] |Coronavirus Infections/complications/*metabolism[MESH] |Disease Susceptibility[MESH] |Grape Seed Extract[MESH] |Humans[MESH] |Mouth Neoplasms/complications/*metabolism[MESH] |Mouthwashes[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/complications/*metabolism[MESH] |Protein Binding[MESH]EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 (epmc).pdf DeepDyve Pubget Overpricing