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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Sens 2020 ; 5 (8): 2596-2603 Nephropedia Template TP
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Rapid Gel Card Agglutination Assays for Serological Analysis Following SARS-CoV-2 Infection in Humans #MMPMID32672954
Alves D; Curvello R; Henderson E; Kesarwani V; Walker JA; Leguizamon SC; McLiesh H; Raghuwanshi VS; Samadian H; Wood EM; McQuilten ZK; Graham M; Wieringa M; Korman TM; Scott TF; Banaszak Holl MM; Garnier G; Corrie SR
ACS Sens 2020[Aug]; 5 (8): 2596-2603 PMID32672954show ga
High-throughput and rapid serology assays to detect the antibody response specific to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in human blood samples are urgently required to improve our understanding of the effects of COVID-19 across the world. Short-term applications include rapid case identification and contact tracing to limit viral spread, while population screening to determine the extent of viral infection across communities is a longer-term need. Assays developed to address these needs should match the ASSURED criteria. We have identified agglutination tests based on the commonly employed blood typing methods as a viable option. These blood typing tests are employed in hospitals worldwide, are high-throughput, fast (10-30 min), and automated in most cases. Herein, we describe the application of agglutination assays to SARS-CoV-2 serology testing by combining column agglutination testing with peptide-antibody bioconjugates, which facilitate red cell cross-linking only in the presence of plasma containing antibodies against SARS-CoV-2. This simple, rapid, and easily scalable approach has immediate application in SARS-CoV-2 serological testing and is a useful platform for assay development beyond the COVID-19 pandemic.