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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Infect+Dis 2021 ; 72 (10): 1834-1837 Nephropedia Template TP
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Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients #MMPMID32672790
Dupont V; Kanagaratnam L; Goury A; Poitevin G; Bard M; Julien G; Bonnivard M; Champenois V; Noel V; Mourvillier B; Nguyen P
Clin Infect Dis 2021[May]; 72 (10): 1834-1837 PMID32672790show ga
Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.