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10.1002/rmv.2144 http://scihub22266oqcxt.onion/10.1002/rmv.2144 32671966!7404358!32671966     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Med+Virol 2020 ; 30 (5): e2144 Nephropedia Template TP {{tp|p=32671966|t=2020. Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV |pdf=|usr=}}{{32671966}} gab.com Text Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV JO: Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32671966 #FOAvip The significantly higher mortality rates seen in the elderly compared with young children during the coronavirus disease 2019 (Covid-19) pandemic is likely to be driven in part by an impaired immune response in older individuals. Cytomegalovirus (CMV) seroprevalence approaches 80% in the elderly. CMV has been shown to accelerate immune ageing by affecting peripheral blood T cell phenotypes and increasing inflammatory mediated cytokines such as IL-6. The elderly with pre-existing but clinically silent CMV infection may therefore be particularly susceptible to severe Covid-19 disease and succumb to a cytokine storm which may have been promoted by CMV. Here, we evaluate the potential role of CMV in those with severe Covid-19 disease and consider how this relationship can be investigated in current research studies. Twit Text FOAVip Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV ????Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32671966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32671966 #FOAvip English Wikipedia <ref>{{Cite pmid|32671966}}</ref> Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV #MMPMID32671966 Kadambari S; Klenerman P; Pollard AJ Rev Med Virol 2020[Sep]; 30 (5): e2144 PMID32671966show ga The significantly higher mortality rates seen in the elderly compared with young children during the coronavirus disease 2019 (Covid-19) pandemic is likely to be driven in part by an impaired immune response in older individuals. Cytomegalovirus (CMV) seroprevalence approaches 80% in the elderly. CMV has been shown to accelerate immune ageing by affecting peripheral blood T cell phenotypes and increasing inflammatory mediated cytokines such as IL-6. The elderly with pre-existing but clinically silent CMV infection may therefore be particularly susceptible to severe Covid-19 disease and succumb to a cytokine storm which may have been promoted by CMV. Here, we evaluate the potential role of CMV in those with severe Covid-19 disease and consider how this relationship can be investigated in current research studies. |*Immunosenescence[MESH] |*Pandemics[MESH] |Age Factors[MESH] |Aged[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |COVID-19[MESH] |Child[MESH] |Coinfection[MESH] |Coronavirus Infections/*epidemiology/immunology/mortality/virology[MESH] |Cytokine Release Syndrome/*epidemiology/immunology/mortality/virology[MESH] |Cytokines/genetics/immunology[MESH] |Cytomegalovirus Infections/*epidemiology/immunology/mortality/virology[MESH] |Cytomegalovirus/immunology/*pathogenicity[MESH] |Disease Progression[MESH] |Humans[MESH] |Pneumonia, Viral/*epidemiology/immunology/mortality/virology[MESH] |SARS-CoV-2[MESH] |Seroepidemiologic Studies[MESH] |Severity of Illness Index[MESH] |Survival Analysis[MESH]Why the elderly appear to be more severely affected by COVID-19: The p(epmc).pdf DeepDyve Pubget Overpricing