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10.1111/bph.15199 http://scihub22266oqcxt.onion/10.1111/bph.15199 32671829!7405164!32671829     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2020 ; 177 (21): 4887-4898 Nephropedia Template TP {{tp|p=32671829|t=2020. Targeting zinc metalloenzymes in coronavirus disease 2019 |pdf=|usr=}}{{32671829}} gab.com Text Targeting zinc metalloenzymes in coronavirus disease 2019 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32671829 #FOAvip Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID-19). An important fact is that zinc is present in proteins of humans and of viruses. Some zinc sites in viral enzymes may serve as drug targets and may liberate zinc ions, thus leading to changes in intracellular concentration of zinc ions, while increased intracellular zinc may induce biological effects in both the host and the virus. Drugs such as chloroquine may contribute to increased intracellular zinc. Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. Twit Text FOAVip Targeting zinc metalloenzymes in coronavirus disease 2019 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32671829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32671829 #FOAvip English Wikipedia <ref>{{Cite pmid|32671829}}</ref> Targeting zinc metalloenzymes in coronavirus disease 2019 #MMPMID32671829 Doboszewska U; Wlaz P; Nowak G; Mlyniec K Br J Pharmacol 2020[Nov]; 177 (21): 4887-4898 PMID32671829show ga Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID-19). An important fact is that zinc is present in proteins of humans and of viruses. Some zinc sites in viral enzymes may serve as drug targets and may liberate zinc ions, thus leading to changes in intracellular concentration of zinc ions, while increased intracellular zinc may induce biological effects in both the host and the virus. Drugs such as chloroquine may contribute to increased intracellular zinc. Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/pharmacology[MESH] |Coronavirus Infections/*drug therapy/enzymology/virology[MESH] |Enzymes/metabolism[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/enzymology/virology[MESH] |SARS-CoV-2[MESH]Targeting zinc metalloenzymes in coronavirus disease 2019 (epmc).pdf DeepDyve Pubget Overpricing