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10.1007/s10995-020-02981-9

http://scihub22266oqcxt.onion/10.1007/s10995-020-02981-9
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32671537!7363497!32671537
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suck abstract from ncbi


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pmid32671537      Matern+Child+Health+J 2020 ; 24 (9): 1099-1103
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  • Using Prenatal Blood Samples to Evaluate COVID-19 Rapid Serologic Tests Specificity #MMPMID32671537
  • Alger J; Cafferata ML; Alvarado T; Ciganda A; Corrales A; Desale H; Drouin A; Fusco D; Garcia J; Gibbons L; Harville E; Lopez W; Lorenzana I; Munoz-Lara F; Palou E; Retes E; Sierra M; Stella C; Xiong X; Zambrano LI; Buekens P
  • Matern Child Health J 2020[Sep]; 24 (9): 1099-1103 PMID32671537show ga
  • INTRODUCTION: Background cross-reactivity with other coronaviruses may reduce the specificity of COVID-19 rapid serologic tests. The vast majority of women attend prenatal care, which is a unique source of population-based blood samples appropriate for validation studies. We used stored 2018 serum samples from an existing pregnancy cohort study to evaluate the specificity of COVID-19 serologic rapid diagnostic tests. METHODS: We randomly selected 120 stored serum samples from pregnant women enrolled in a cohort in 2018 in Tegucigalpa, Honduras, at least 1 year before the COVID-19 pandemic. We used stored serum to evaluate four lateral flow rapid diagnostic tests, following manufacturers' instructions. Pictures were taken for all tests and read by two blinded trained evaluators. RESULTS: We evaluated 120, 80, 90, and 90 samples, respectively. Specificity for both IgM and IgG was 100% for the first two tests (95% confidence intervals [CI] 97.0-100 and 95.5-100, respectively). The third test had a specificity of 98.9% (95% CI 94.0-100) for IgM and 94.4% (95% CI 87.5-98.2) for IgG. The fourth test had a specificity of 88.9% (95% CI 80.5-94.5) for IgM and 100% (95% CI 96.0-100) for IgG. DISCUSSION: COVID-19 serologic rapid tests are of variable specificity. Blood specimens from sentinel prenatal clinics provide an opportunity to validate serologic tests with population-based samples.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/blood/*diagnosis/epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/*diagnosis/epidemiology[MESH]
  • |Predictive Value of Tests[MESH]
  • |Pregnancy[MESH]
  • |Prenatal Care/*methods[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Serologic Tests[MESH]


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