A Low Viral Dose in COVID-19 Patient: A Case Report #MMPMID32671013
Li Y; Hu X; Tu Y; Wu T; Wang B; Ma H; Zeng W; Zhao D; Mengist HM; Kombe AJK; Zheng M; Xu Y; Jin T
Front Public Health 2020[]; 8 (ä): 339 PMID32671013show ga
SARS-CoV-2 outbreak has attracted global attention. Verifying the presence of viral RNA is the gold standard for the diagnosis of COVID-19. However, RT-qPCR diagnosis often fails to catch infected patients, because of inconsistent swab sample collection. Here we report a case that showed 5 consecutive negative and 1 low-viral- dose RT-qPCR results during illness spanning over 20 days. Clinical symptoms suggest SARS-CoV-2 infection with typical ground glass like a lung in computed tomography. SARS-CoV-2 infection was serologically confirmed by the presence of anti-SARS-CoV-2 specific antibodies in patients' serum. Finally, a high level of protective IgG was produced after the patient recovered. Surprisingly, as a barber and a housewife staying at home for the first 2 weeks after the onset of illness, none of the close contacts were infected, showing a case of low viral load and low infectivity in this patient.
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Front+Public+Health 2020 ; 8 (ä): 339
