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10.3389/fimmu.2020.01181

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01181
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32670279!7329983!32670279
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suck abstract from ncbi

pmid32670279      Front+Immunol 2020 ; 11 (ä): 1181
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  • Current Challenges in Vaccinology #MMPMID32670279
  • Kennedy RB; Ovsyannikova IG; Palese P; Poland GA
  • Front Immunol 2020[]; 11 (ä): 1181 PMID32670279show ga
  • The development of vaccines, which prime the immune system to respond to future infections, has led to global declines in morbidity and mortality from dreadful infectious communicable diseases. However, many pathogens of public health importance are highly complex and/or rapidly evolving, posing unique challenges to vaccine development. Several of these challenges include an incomplete understanding of how immunity develops, host and pathogen genetic variability, and an increased societal skepticism regarding vaccine safety. In particular, new high-dimensional omics technologies, aided by bioinformatics, are driving new vaccine development (vaccinomics). Informed by recent insights into pathogen biology, host genetic diversity, and immunology, the increasing use of genomic approaches is leading to new models and understanding of host immune system responses that may provide solutions in the rapid development of novel vaccine candidates.
  • |*Computational Biology[MESH]
  • |*Vaccines[MESH]
  • |Animals[MESH]
  • |Communicable Disease Control/*methods[MESH]
  • |Humans[MESH]


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