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10.3389/fimmu.2020.01102 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01102 32670273!7326128!32670273     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1102 Nephropedia Template TP {{tp|p=32670273|t=2020. Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adjunctive Therapy?|pdf=|usr=}}{{32670273}} gab.com Text Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adjunctive Therapy JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32670273 #FOAvip With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is critical to come up with an effective treatment against SARS-CoV-2. Studies suggest that mortality due to COVID 19 is mainly attributed to the hyper inflammatory response leading to cytokine storm and ARDS in infected patients. Sphingosine-1-phosphate receptor 1 (S1PR1) analogs, AAL-R and RP-002, have earlier provided in-vivo protection from the pathophysiological response during H1N1 influenza infection and improved mortality. Recently, it was shown that the treatment with sphingosine-1-phosphate receptor 1 analog, CYM5442, resulted in the significant dampening of the immune response upon H1N1 challenge in mice and improved survival of H1N1 infected mice in combination with an antiviral drug, oseltamivir. Hence, here we suggest to investigate the possible utility of using S1P analogs to treat COVID-19. Twit Text FOAVip Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adjunctive Therapy ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32670273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32670273 #FOAvip English Wikipedia <ref>{{Cite pmid|32670273}}</ref> Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adjunctive Therapy? #MMPMID32670273 Naz F; Arish M Front Immunol 2020[]; 11 (ä): 1102 PMID32670273show ga With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is critical to come up with an effective treatment against SARS-CoV-2. Studies suggest that mortality due to COVID 19 is mainly attributed to the hyper inflammatory response leading to cytokine storm and ARDS in infected patients. Sphingosine-1-phosphate receptor 1 (S1PR1) analogs, AAL-R and RP-002, have earlier provided in-vivo protection from the pathophysiological response during H1N1 influenza infection and improved mortality. Recently, it was shown that the treatment with sphingosine-1-phosphate receptor 1 analog, CYM5442, resulted in the significant dampening of the immune response upon H1N1 challenge in mice and improved survival of H1N1 infected mice in combination with an antiviral drug, oseltamivir. Hence, here we suggest to investigate the possible utility of using S1P analogs to treat COVID-19. |Animals[MESH] |Betacoronavirus/drug effects/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy[MESH] |Cytokine Release Syndrome/*prevention & control[MESH] |Humans[MESH] |Indans/*therapeutic use[MESH] |Influenza A Virus, H1N1 Subtype/drug effects[MESH] |Lysophospholipids/*agonists[MESH] |Mice[MESH] |Orthomyxoviridae Infections/drug therapy/prevention & control[MESH] |Oseltamivir/therapeutic use[MESH] |Oxadiazoles/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |SARS-CoV-2[MESH] |Sphingosine-1-Phosphate Receptors/*metabolism[MESH]Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adju(epmc).pdf DeepDyve Pubget Overpricing