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10.3389/fphys.2020.00388

http://scihub22266oqcxt.onion/10.3389/fphys.2020.00388
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suck abstract from ncbi


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pmid32670073      Front+Physiol 2020 ; 11 (ä): 388
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  • The Contribution of Surface Tension-Dependent Alveolar Septal Stress Concentrations to Ventilation-Induced Lung Injury in the Acute Respiratory Distress Syndrome #MMPMID32670073
  • Perlman CE
  • Front Physiol 2020[]; 11 (ä): 388 PMID32670073show ga
  • In the acute respiratory distress syndrome (ARDS), surface tension, T, is likely elevated. And mechanical ventilation of ARDS patients causes ventilation-induced lung injury (VILI), which is believed to be proportional to T. However, the mechanisms through which elevated T may contribute to VILI have been under-studied. This conceptual analysis considers experimental and theoretical evidence for static and dynamic mechanical mechanisms, at the alveolar scale, through which elevated T exacerbates VILI; potential causes of elevated T in ARDS; and T-dependent means of reducing VILI. In the last section, possible means of reducing T and improving the efficacy of recruitment maneuvers during mechanical ventilation of ARDS patients are discussed.
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