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10.1126/science.abc8511

http://scihub22266oqcxt.onion/10.1126/science.abc8511
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32669297!7402624!32669297
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suck abstract from ncbi


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pmid32669297      Science 2020 ; 369 (6508): ä
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  • Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications #MMPMID32669297
  • Mathew D; Giles JR; Baxter AE; Oldridge DA; Greenplate AR; Wu JE; Alanio C; Kuri-Cervantes L; Pampena MB; D'Andrea K; Manne S; Chen Z; Huang YJ; Reilly JP; Weisman AR; Ittner CAG; Kuthuru O; Dougherty J; Nzingha K; Han N; Kim J; Pattekar A; Goodwin EC; Anderson EM; Weirick ME; Gouma S; Arevalo CP; Bolton MJ; Chen F; Lacey SF; Ramage H; Cherry S; Hensley SE; Apostolidis SA; Huang AC; Vella LA; Betts MR; Meyer NJ; Wherry EJ
  • Science 2020[Sep]; 369 (6508): ä PMID32669297show ga
  • Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable with that in uninfected individuals. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.
  • |Adaptive Immunity[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |B-Lymphocyte Subsets/immunology[MESH]
  • |B-Lymphocytes/*immunology[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Cytokines/blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunologic Memory[MESH]
  • |Lymphocyte Activation[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Plasma Cells/immunology[MESH]
  • |Pneumonia, Viral/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |T-Lymphocyte Subsets/immunology[MESH]
  • |T-Lymphocytes, Helper-Inducer/immunology[MESH]
  • |T-Lymphocytes/*immunology[MESH]
  • |Time Factors[MESH]


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