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10.1126/sciimmunol.abd7114 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abd7114 32669287!7402634!32669287     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (49): ä Nephropedia Template TP {{tp|p=32669287|t=2020. Comprehensive mapping of immune perturbations associated with severe COVID-19 |pdf=|usr=}}{{32669287}} gab.com Text Comprehensive mapping of immune perturbations associated with severe COVID-19 JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32669287 #FOAvip Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. Twit Text FOAVip Comprehensive mapping of immune perturbations associated with severe COVID-19 ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32669287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32669287 #FOAvip English Wikipedia <ref>{{Cite pmid|32669287}}</ref> Comprehensive mapping of immune perturbations associated with severe COVID-19 #MMPMID32669287 Kuri-Cervantes L; Pampena MB; Meng W; Rosenfeld AM; Ittner CAG; Weisman AR; Agyekum RS; Mathew D; Baxter AE; Vella LA; Kuthuru O; Apostolidis SA; Bershaw L; Dougherty J; Greenplate AR; Pattekar A; Kim J; Han N; Gouma S; Weirick ME; Arevalo CP; Bolton MJ; Goodwin EC; Anderson EM; Hensley SE; Jones TK; Mangalmurti NS; Luning Prak ET; Wherry EJ; Meyer NJ; Betts MR Sci Immunol 2020[Jul]; 5 (49): ä PMID32669287show ga Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. |Aged[MESH] |B-Lymphocyte Subsets/*immunology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Clonal Selection, Antigen-Mediated/immunology[MESH] |Coronavirus Infections/*immunology/pathology[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Immunologic Memory/immunology[MESH] |Lymphocyte Activation/immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/pathology[MESH] |SARS-CoV-2[MESH]Comprehensive mapping of immune perturbations associated with severe C(epmc).pdf DeepDyve Pubget Overpricing