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10.1038/s41586-020-2550-z http://scihub22266oqcxt.onion/10.1038/s41586-020-2550-z 32668444!ä!32668444 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 584 (7821): 457-462 Nephropedia Template TP {{tp|p=32668444|t=2020. SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls |pdf=|usr=}}{{32668444}} gab.com Text SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32668444 #FOAvip Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections(1). Little is known about the presence in humans of pre-existing memory T cells that have the potential to recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we studied T cell responses against the structural (nucleocapsid (N) protein) and non-structural (NSP7 and NSP13 of ORF1) regions of SARS-CoV-2 in individuals convalescing from coronavirus disease 2019 (COVID-19) (n = 36). In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein. Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARS-CoV infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2. We also detected SARS-CoV-2-specific T cells in individuals with no history of SARS, COVID-19 or contact with individuals who had SARS and/or COVID-19 (n = 37). SARS-CoV-2-specific T cells in uninfected donors exhibited a different pattern of immunodominance, and frequently targeted NSP7 and NSP13 as well as the N protein. Epitope characterization of NSP7-specific T cells showed the recognition of protein fragments that are conserved among animal betacoronaviruses but have low homology to 'common cold' human-associated coronaviruses. Thus, infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein. Understanding how pre-existing N- and ORF1-specific T cells that are present in the general population affect the susceptibility to and pathogenesis of SARS-CoV-2 infection is important for the management of the current COVID-19 pandemic. Twit Text FOAVip SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32668444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32668444 #FOAvip English Wikipedia <ref>{{Cite pmid|32668444}}</ref> SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls #MMPMID32668444 Le Bert N; Tan AT; Kunasegaran K; Tham CYL; Hafezi M; Chia A; Chng MHY; Lin M; Tan N; Linster M; Chia WN; Chen MI; Wang LF; Ooi EE; Kalimuddin S; Tambyah PA; Low JG; Tan YJ; Bertoletti A Nature 2020[Aug]; 584 (7821): 457-462 PMID32668444show ga Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections(1). Little is known about the presence in humans of pre-existing memory T cells that have the potential to recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we studied T cell responses against the structural (nucleocapsid (N) protein) and non-structural (NSP7 and NSP13 of ORF1) regions of SARS-CoV-2 in individuals convalescing from coronavirus disease 2019 (COVID-19) (n = 36). In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein. Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARS-CoV infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2. We also detected SARS-CoV-2-specific T cells in individuals with no history of SARS, COVID-19 or contact with individuals who had SARS and/or COVID-19 (n = 37). SARS-CoV-2-specific T cells in uninfected donors exhibited a different pattern of immunodominance, and frequently targeted NSP7 and NSP13 as well as the N protein. Epitope characterization of NSP7-specific T cells showed the recognition of protein fragments that are conserved among animal betacoronaviruses but have low homology to 'common cold' human-associated coronaviruses. Thus, infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein. Understanding how pre-existing N- and ORF1-specific T cells that are present in the general population affect the susceptibility to and pathogenesis of SARS-CoV-2 infection is important for the management of the current COVID-19 pandemic. |Betacoronavirus/chemistry/*immunology[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Cross Reactions/immunology[MESH] |Humans[MESH] |Immunodominant Epitopes/immunology[MESH] |Nucleocapsid Proteins/chemistry/immunology[MESH] |Pandemics[MESH] |Phosphoproteins[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/*immunology[MESH]SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and(epmc).pdf DeepDyve Pubget Overpricing