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10.1016/j.dsx.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.07.003
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32668399!7347476!32668399
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suck abstract from ncbi

pmid32668399      Diabetes+Metab+Syndr 2020 ; 14 (5): 1143-1146
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  • Hypoglycemia at the time of Covid-19 pandemic #MMPMID32668399
  • Shah K; Tiwaskar M; Chawla P; Kale M; Deshmane R; Sowani A
  • Diabetes Metab Syndr 2020[Sep]; 14 (5): 1143-1146 PMID32668399show ga
  • BACKGROUND: Hypoglycemia is the limiting factor in the glycemic management of diabetes, which need to be addressed critically to avoid complications. Lockdown because of new coronavirus strain (COVID-19) pandemic has further complicated the issue of hypoglycemia due to limitations in access to food, outpatient clinics, pathological services and medicines. AIM: To assess the factors associated with the risk of hypoglycemia during April-May 2020 lockdown in people with type 2 diabetes mellitus. METHODOLOGY: We analyzed the data retrospectively from 146 patients of type 2 diabetes mellitus (T2DM) reporting to the emergency department (ED) during lockdown period with symptoms suggestive of hypoglycemia. RESULTS: The majority of patients were male (90/146) with a mean age of 59.88 +/- 10.09 years and a mean random blood glucose level of 57.67 +/- 9.00 mg/dL. Two-third of patients (70.83%) had level 1 hypoglycemia, while level 2 hypoglycemia was reported in 29.16% of patients. A combination of Metformin and Sulfonylureas (SU) was most commonly associated with the risk of hypoglycemia (65.75%) followed by insulin (33.56%). Subjects who received insulin reported a lower blood glucose value (50.75 +/- 8.20 mg/dL) as compared to those receiving a combination of metformin and SU (60.95 +/- 7.10 mg/dl). 330.56% of patients who had received prophylaxis hydroxychloroquine (HCQ) 400 mg twice a day along with the routine anti-hyperglycemic agents without their dose adjustment reported hypoglycemia. Patients with hypertension, micro-vascular, macro-vascular complications, and coexistent with each other had a higher propensity to the risk of hypoglycemia (46.58%, 33.56%, 23.29%, and 32.88%) respectively. CONCLUSION: The COVID-19 lockdown has shown to influence the risk of hypoglycemia in patients with T2DM, especially those receiving SU, insulin, HCQ especially in patients with associated co-morbidities. Patient education, support, and telemedicine plays a pivotal role to prevent hypoglycemia.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |Biomarkers/analysis[MESH]
  • |Blood Glucose/analysis[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/transmission/virology[MESH]
  • |Diabetes Mellitus, Type 2/*physiopathology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Glycated Hemoglobin/analysis[MESH]
  • |Humans[MESH]
  • |Hypoglycemia/*epidemiology/virology[MESH]
  • |Incidence[MESH]
  • |India/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/transmission/virology[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]


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