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10.1016/j.ejps.2020.105465 http://scihub22266oqcxt.onion/10.1016/j.ejps.2020.105465 32668312!7354764!32668312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharm+Sci 2020 ; 153 (ä): 105465 Nephropedia Template TP {{tp|p=32668312|t=2020. A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection |pdf=|usr=}}{{32668312}} gab.com Text A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection JO: Eur J Pharm Sci http://www.kidney.de/pget.php?&tw=1&pmid=32668312 #FOAvip COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific antiviral agent(s) and a vaccine for SARS-CoV-2, the world health organization (WHO) adopted the strategy of repurposing existing medications to treat COVID-19. Iron oxide nanoparticles (IONPs) were previously approved by the US food and drug administration (FDA) for anemia treatment and studies have also demonstrated its antiviral activity in vitro. Therefore, we performed a docking study to explore the interaction of IONPs (Fe(2)O(3) and Fe(3)O(4)) with the spike protein receptor binding domain (S1-RBD) of SARS-CoV-2 that is required for virus attachment to the host cell receptors. A similar docking analysis was also performed with hepatitis C virus (HCV) glycoproteins E1 and E2. These studies revealed that both Fe(2)O(3) and Fe(3)O(4) interacted efficiently with the SARS-CoV-2 S1-RBD and to HCV glycoproteins, E1 and E2. Fe(3)O(4) formed a more stable complex with S1-RBD whereas Fe(2)O(3) favored HCV E1 and E2. These interactions of IONPs are expected to be associated with viral proteins conformational changes and hence, viral inactivation. Therefore, we recommend FDA-approved-IONPs to proceed for COVID-19 treatment clinical trials. Twit Text FOAVip A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection ????Eur J Pharm Sci http://www.kidney.de/pget.php?&tw=1&pmid=32668312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32668312 #FOAvip English Wikipedia <ref>{{Cite pmid|32668312}}</ref> A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection #MMPMID32668312 Abo-Zeid Y; Ismail NSM; McLean GR; Hamdy NM Eur J Pharm Sci 2020[Oct]; 153 (ä): 105465 PMID32668312show ga COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific antiviral agent(s) and a vaccine for SARS-CoV-2, the world health organization (WHO) adopted the strategy of repurposing existing medications to treat COVID-19. Iron oxide nanoparticles (IONPs) were previously approved by the US food and drug administration (FDA) for anemia treatment and studies have also demonstrated its antiviral activity in vitro. Therefore, we performed a docking study to explore the interaction of IONPs (Fe(2)O(3) and Fe(3)O(4)) with the spike protein receptor binding domain (S1-RBD) of SARS-CoV-2 that is required for virus attachment to the host cell receptors. A similar docking analysis was also performed with hepatitis C virus (HCV) glycoproteins E1 and E2. These studies revealed that both Fe(2)O(3) and Fe(3)O(4) interacted efficiently with the SARS-CoV-2 S1-RBD and to HCV glycoproteins, E1 and E2. Fe(3)O(4) formed a more stable complex with S1-RBD whereas Fe(2)O(3) favored HCV E1 and E2. These interactions of IONPs are expected to be associated with viral proteins conformational changes and hence, viral inactivation. Therefore, we recommend FDA-approved-IONPs to proceed for COVID-19 treatment clinical trials. |*Molecular Docking Simulation[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drug Approval[MESH] |Drug Repositioning[MESH] |Ferric Compounds/*therapeutic use[MESH] |Humans[MESH] |Metal Nanoparticles/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Protein Conformation[MESH] |Spike Glycoprotein, Coronavirus/drug effects[MESH] |United States[MESH] |United States Food and Drug Administration[MESH]A molecular docking study repurposes FDA approved iron oxide nanoparti(epmc).pdf DeepDyve Pubget Overpricing