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10.1111/jth.15016 http://scihub22266oqcxt.onion/10.1111/jth.15016 32668058!7405476!32668058     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Thromb+Haemost 2020 ; 18 (9): 2215-2219 Nephropedia Template TP {{tp|p=32668058|t=2020. Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis |pdf=|usr=}}{{32668058}} gab.com Text Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=32668058 #FOAvip BACKGROUND: Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, and acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. OBJECTIVE: We aimed to assess fibrinolytic activity and thrombin generation in 78 Covid-19 patients. PATIENTS AND METHODS: Forty-eight patients admitted to the intensive care unit and 30 patients admitted to the internal medicine department were included in the study. All patients received thromboprophylaxis. We measured fibrinolytic parameters (tissue plasminogen activator, PAI-1, thrombin activatable fibrinolysis inhibitor, alpha2 anti-plasmin, and tissue plasminogen activator-modified ROTEM device), thrombin generation, and other coagulation tests (D-dimer, fibrinogen, factor VIII, antithrombin). RESULTS AND CONCLUSIONS: We observed two key findings: a high thrombin generation capacity that remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI-1 levels. A modified ROTEM is able to detect both hypercoagulability and hypofibrinolysis simultaneously in Covid-19 patients with thrombosis. Twit Text FOAVip Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=32668058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32668058 #FOAvip English Wikipedia <ref>{{Cite pmid|32668058}}</ref> Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis #MMPMID32668058 Nougier C; Benoit R; Simon M; Desmurs-Clavel H; Marcotte G; Argaud L; David JS; Bonnet A; Negrier C; Dargaud Y J Thromb Haemost 2020[Sep]; 18 (9): 2215-2219 PMID32668058show ga BACKGROUND: Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, and acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. OBJECTIVE: We aimed to assess fibrinolytic activity and thrombin generation in 78 Covid-19 patients. PATIENTS AND METHODS: Forty-eight patients admitted to the intensive care unit and 30 patients admitted to the internal medicine department were included in the study. All patients received thromboprophylaxis. We measured fibrinolytic parameters (tissue plasminogen activator, PAI-1, thrombin activatable fibrinolysis inhibitor, alpha2 anti-plasmin, and tissue plasminogen activator-modified ROTEM device), thrombin generation, and other coagulation tests (D-dimer, fibrinogen, factor VIII, antithrombin). RESULTS AND CONCLUSIONS: We observed two key findings: a high thrombin generation capacity that remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI-1 levels. A modified ROTEM is able to detect both hypercoagulability and hypofibrinolysis simultaneously in Covid-19 patients with thrombosis. |*Fibrinolysis[MESH] |Adult[MESH] |Aged[MESH] |Blood Coagulation[MESH] |Blood Coagulation Factors/metabolism[MESH] |Blood Coagulation Tests[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/*blood/*complications[MESH] |Critical Care[MESH] |Female[MESH] |Humans[MESH] |Inflammation[MESH] |Intensive Care Units[MESH] |Male[MESH] |Middle Aged[MESH] |Renal Replacement Therapy[MESH] |Respiration, Artificial[MESH] |Risk[MESH] |Thrombin/*metabolism[MESH] |Thrombosis/*complications[MESH]Hypofibrinolytic state and high thrombin generation may play a major r(epmc).pdf DeepDyve Pubget Overpricing