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10.1093/femspd/ftaa036 http://scihub22266oqcxt.onion/10.1093/femspd/ftaa036 32667665!7454646!32667665     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32667665&cmd=llinks): Failed to open stream: HTTP request failed! 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Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19) |pdf=|usr=}}{{32667665}} gab.com Text Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19) JO: Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=32667665 #FOAvip The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in the disease and that the regulation of genes involved in neutrophil degranulation was disrupted, suggesting an intense battle between SARS-CoV-2 and humans. Furthermore, we implemented a coexpression drug repositioning analysis, cogena, and identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline). Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5-7) published by the National Health Commission of the P.R. of China. Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia. Twit Text FOAVip Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19) ????Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=32667665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32667665 #FOAvip English Wikipedia <ref>{{Cite pmid|32667665}}</ref> Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19) #MMPMID32667665 Jia Z; Song X; Shi J; Wang W; He K Pathog Dis 2020[Jun]; 78 (4): ä PMID32667665show ga The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in the disease and that the regulation of genes involved in neutrophil degranulation was disrupted, suggesting an intense battle between SARS-CoV-2 and humans. Furthermore, we implemented a coexpression drug repositioning analysis, cogena, and identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline). Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5-7) published by the National Health Commission of the P.R. of China. Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia. |*Drug Repositioning[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects[MESH] |Bronchoalveolar Lavage Fluid/chemistry[MESH] |COVID-19[MESH] |Cell Degranulation/immunology[MESH] |Coronavirus Infections/*drug therapy[MESH] |Endocytosis/immunology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Lysosomes/immunology[MESH] |Molecular Docking Simulation[MESH] |Neutrophil Activation/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Ribavirin/*pharmacology[MESH] |SARS-CoV-2[MESH] |Saquinavir/*pharmacology[MESH]Transcriptome-based drug repositioning for coronavirus disease 2019 (C(epmc).pdf DeepDyve Pubget Overpricing