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10.1099/jgv.0.001469 http://scihub22266oqcxt.onion/10.1099/jgv.0.001469 32667280!7660454!32667280     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2020 ; 101 (10): 1085-1089 Nephropedia Template TP {{tp|p=32667280|t=2020. A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a |pdf=|usr=}}{{32667280}} gab.com Text A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=32667280 #FOAvip Identification of the full complement of genes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be difficult to detect using conventional computational approaches, whereas high-throughput experimental approaches - such as ribosome profiling - cannot distinguish translation of functional peptides from regulatory translation or translational noise. By studying regions showing enhanced conservation at synonymous sites in alignments of SARS-CoV-2 and related viruses (subgenus Sarbecovirus) and correlating the results with the conserved presence of an open reading frame (ORF) and a plausible translation mechanism, a putative new gene - ORF3c - was identified. ORF3c overlaps ORF3a in an alternative reading frame. A recently published ribosome profiling study confirmed that ORF3c is indeed translated during infection. ORF3c is conserved across the subgenus Sarbecovirus, and encodes a 40-41 amino acid predicted transmembrane protein. Twit Text FOAVip A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=32667280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32667280 #FOAvip English Wikipedia <ref>{{Cite pmid|32667280}}</ref> A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a #MMPMID32667280 Firth AE J Gen Virol 2020[Oct]; 101 (10): 1085-1089 PMID32667280show ga Identification of the full complement of genes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be difficult to detect using conventional computational approaches, whereas high-throughput experimental approaches - such as ribosome profiling - cannot distinguish translation of functional peptides from regulatory translation or translational noise. By studying regions showing enhanced conservation at synonymous sites in alignments of SARS-CoV-2 and related viruses (subgenus Sarbecovirus) and correlating the results with the conserved presence of an open reading frame (ORF) and a plausible translation mechanism, a putative new gene - ORF3c - was identified. ORF3c overlaps ORF3a in an alternative reading frame. A recently published ribosome profiling study confirmed that ORF3c is indeed translated during infection. ORF3c is conserved across the subgenus Sarbecovirus, and encodes a 40-41 amino acid predicted transmembrane protein. |Amino Acid Sequence/genetics[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections/virology[MESH] |Genes, Overlapping/*genetics[MESH] |Humans[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/virology[MESH] |Reading Frames/*genetics[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Viral Regulatory and Accessory Proteins/genetics[MESH]A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF(epmc).pdf DeepDyve Pubget Overpricing